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Titolo:
Circadian variation of the urinary 6 beta-hydroxycortisol to cortisol ratio that would reflect hepatic CYP3A activity
Autore:
Ohno, M; Yamaguchi, I; Ito, T; Saiki, K; Yamamoto, I; Azuma, J;
Indirizzi:
Osaka Univ, Grad Sch Pharmaceut Sci, Dept Clin Evaluat Med & Therapeut, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 erapeut, Suita, Osaka 5650871, Japan Osaka Pharmacol Res Clin, Osaka, Japan Osaka Pharmacol Res Clin Osaka Japan a Pharmacol Res Clin, Osaka, Japan Kobe Pharmaceut Univ, Kobe, Hyogo 658, Japan Kobe Pharmaceut Univ Kobe Hyogo Japan 658 ut Univ, Kobe, Hyogo 658, Japan
Titolo Testata:
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
fascicolo: 11-12, volume: 55, anno: 2000,
pagine: 861 - 865
SICI:
0031-6970(200002/03)55:11-12<861:CVOTU6>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENZYME-INDUCTION; CYTOCHROME-P450 3A4; HUMANS; EXCRETION; PHARMACOKINETICS; METABOLISM; TIME; CHRONOPHARMACOKINETICS; FLUCONAZOLE; NIFEDIPINE;
Keywords:
6 beta-hydroxycortisol; cortisol; circadian rhythm;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Azuma, J Osaka Univ, Grad Sch Pharmaceut Sci, Dept Clin Evaluat Med & Therapeut, 1-6 Yamada Oka, Suita, Osaka 5650871, Japan Osaka Univ 1-6 Yamada Oka Suita Osaka Japan 5650871 650871, Japan
Citazione:
M. Ohno et al., "Circadian variation of the urinary 6 beta-hydroxycortisol to cortisol ratio that would reflect hepatic CYP3A activity", EUR J CL PH, 55(11-12), 2000, pp. 861-865

Abstract

Objectives: Chronopharmacokinetics of drugs metabolized by cytochrome P-450 3A (CYP3A) has been reported recently; however, little is studied on intraindividual circadian variation in CYP3A activity in human. The aim of thisstudy was to assess the intraindividual diurnal variation and day-to-day variation of the urinary 6 beta-hydroxycortisol to cortisol ratio, a noninvasive index of human CYP3A activity. Methods: Urine samples from ten healthy Japanese men were collected over four time intervals (0900 hours to 1300 hours, 1300 hours to 1700 hours, 1700 hours to 2100 hours and 2100 hours to 0900 hours) on days 1, 5 and 14 to verify diurnal variation, and 24-h urine was collected to study day-to-day variation over 2 weeks. Urinary 6 beta-hydroxycortisol and cortisol were determined by means of high-performance liquid chromatography/atmospheric pressure chemical ionization-mass spectrometry. Results: The ratio of urinary 6 beta-hydroxycortisol to cortisol exhibitednoteworthy diurnal variation intraindividually; 2.8-fold on average. However, day-do-day intra-individual variation of the ratio was not observed over 2 weeks; the coefficient of variation was 11.9 +/- 3.0%. Conclusion: The result indicates that imprudent use of random urine has a great risk of false evaluation in assessment of the 6 beta-hydroxycortisol to cortisol ratio and that the ratio in 24-h urine samples provides a more robust measure of the inter-individual difference of this metabolic ratio, which to a certain but not complete extent represents the CYP3A activity.

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Documento generato il 26/01/20 alle ore 10:10:42