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Titolo:
The role of the Sid1p kinase and Cdc14p in regulating the onset of cytokinesis in fission yeast
Autore:
Guertin, DA; Chang, L; Irshad, F; Gould, KL; McCollum, D;
Indirizzi:
Univ Massachusetts, Sch Med, Dept Mol Genet & Microbiol, Worcester, MA 01605 USA Univ Massachusetts Worcester MA USA 01605 robiol, Worcester, MA 01605 USA Vanderbilt Univ, Howard Hughes Med Inst, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Med Inst, Nashville, TN 37232 USA Vanderbilt Univ, Dept Cell Biol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Cell Biol, Nashville, TN 37232 USA
Titolo Testata:
EMBO JOURNAL
fascicolo: 8, volume: 19, anno: 2000,
pagine: 1803 - 1815
SICI:
0261-4189(20000417)19:8<1803:TROTSK>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-DIVISION CYCLE; SPINDLE POLE BODY; SISTER-CHROMATID SEPARATION; ANAPHASE-PROMOTING COMPLEX; SCHIZOSACCHAROMYCES-POMBE; SEPTUM FORMATION; PROTEIN-KINASE; BUDDING YEAST; CHECKPOINT PATHWAY; MITOTIC CHECKPOINT;
Keywords:
cde 7; cdc14; cytokinesis; Schizosaccharomyces pombe; sid1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: McCollum, D Univ Massachusetts, Sch Med, Dept Mol Genet & Microbiol, 377 Plantat St, Worcester, MA 01605 USA Univ Massachusetts 377 Plantat St Worcester MA USA 01605 5 USA
Citazione:
D.A. Guertin et al., "The role of the Sid1p kinase and Cdc14p in regulating the onset of cytokinesis in fission yeast", EMBO J, 19(8), 2000, pp. 1803-1815

Abstract

Coordination of mitosis and cytokinesis is crucial for ensuring proper chromosome segregation and genomic stability. In Schizosaccharomyces pombe, the sid genes (cdc7, cdc11, cdc14, spg1, sid1, sid2 and sid4) define a signaling pathway that regulates septation and cytokinesis. Here we describe the characterization of a novel protein kinase, Sid1p, Sid1p localizes asymmetrically to one spindle pole body (SPB) in anaphase. Sid1p localization is maintained during medial ring constriction and septum synthesis and disappears prior to cell separation. Additionally, we found that Cdc14p is in a complex with Sid1p. Epistasis analysis places Sid1p-Cdc14p downstream of Spg1p-Cdc7p but upstream of Sid2p, Finally, we show that cyclin proteolysis during mitosis is unaffected by inactivating the sid pathway; in fact, loss of Cdc2-cyclin activity promotes Sid1p-Cdc14p association with the SPB, possibly providing a mechanism that couples cytokinesis with mitotic exit.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/05/20 alle ore 08:20:12