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Titolo:
Apoptosis induction by arsenic: mechanisms of action and possible clinicalapplications for treating therapy-resistant cancers
Autore:
Bode, A; Dong, ZG;
Indirizzi:
Univ Minnesota, Hormel Inst, Austin, MN 55912 USA Univ Minnesota Austin MN USA 55912 ota, Hormel Inst, Austin, MN 55912 USA
Titolo Testata:
DRUG RESISTANCE UPDATES
fascicolo: 1, volume: 3, anno: 2000,
pagine: 21 - 29
SICI:
1368-7646(2000)3:1<21:AIBAMO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE PROMYELOCYTIC LEUKEMIA; NF-KAPPA-B; ACTIVATED PROTEIN-KINASES; IN-VITRO; SODIUM ARSENITE; MULTIDRUG-RESISTANCE; P53-DEFICIENT MICE; TRIOXIDE AS2O3; CELL APOPTOSIS; NB4 CELLS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Dong, ZG Univ Minnesota, Hormel Inst, 801 16th Ave NE, Austin, MN 55912 USA Univ Minnesota 801 16th Ave NE Austin MN USA 55912 , MN 55912 USA
Citazione:
A. Bode e Z.G. Dong, "Apoptosis induction by arsenic: mechanisms of action and possible clinicalapplications for treating therapy-resistant cancers", DRUG RESIST, 3(1), 2000, pp. 21-29

Abstract

Arsenic, a known carcinogen, may be useful in cancer treatment. Arsenic may be effective in counteracting drug resistance because it appears to induce apoptosis in tumor cells independently of p53 activation, thereby allowing it to be directed against p53-defective cancers. The role of MAP kinases in arsenic-induced apoptosis in tumor cells is important and may be influenced by reactive oxygen species or glutathione. This review focuses on recent findings from this and other laboratories regarding the mechanism(s) of arsenic-induced apoptosis in tumor cells and considers their relevance in the clinical treatment of therapy-resistant cancers. (C) 2000 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:13:31