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Titolo:
Naltrexone and lofexidine combination treatment compared with conventionallofexidine treatment for in-patient opiate detoxification
Autore:
Buntwal, N; Bearn, J; Gossop, M; Strang, J;
Indirizzi:
Bethlem Royal & Maudsley Hosp, Alcohol Unit, Beckenham BR3 3BX, Kent, England Bethlem Royal & Maudsley Hosp Beckenham Kent England BR3 3BX ent, England
Titolo Testata:
DRUG AND ALCOHOL DEPENDENCE
fascicolo: 2, volume: 59, anno: 2000,
pagine: 183 - 188
SICI:
0376-8716(20000501)59:2<183:NALCTC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPIOID DETOXIFICATION; WITHDRAWAL SYMPTOMS; ABRUPT WITHDRAWAL; RANDOMIZED TRIAL; METHADONE; CLONIDINE; NALOXONE; INDUCTION; PROGRAMS; ADDICTS;
Keywords:
lofexidine; naltrexone; opiate detoxification;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Buntwal, N Bethlem Royal & Maudsley Hosp, Alcohol Unit, Monks Orchard Rd, Beckenham BR3 3BX, Kent, England Bethlem Royal & Maudsley Hosp Monks Orchard Rd Beckenham Kent England BR3 3BX
Citazione:
N. Buntwal et al., "Naltrexone and lofexidine combination treatment compared with conventionallofexidine treatment for in-patient opiate detoxification", DRUG AL DEP, 59(2), 2000, pp. 183-188

Abstract

This study compares a naltrexone/lofexidine combination treatment with a 7-day course of lofexidine alone in the treatment of opiate withdrawal in 22opiate-dependent patients. Withdrawal symptoms were significantly less severe on days 4-7, and 9-13, in the naltrexone/lofexidine combination group. There were no significant differences in the percentage of patients completing detoxification or in the mean length of stay for the two groups. Both treatments had similar, minimal effects on blood pressure. The naltrexone/lofexidine combination was associated with a more rapid resolution of the opiate withdrawal syndrome than a 7-day lofexidine-only treatment schedule, without substantial increases in withdrawal symptoms or hypotensive side-effects. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:33:17