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Titolo:
Renal function in compensated hepatic cirrhosis: Effects of an amino acid infusion and relationship with nitric acid
Autore:
Rodriguez, AS; Martin, AO; Oterino, JAM; Blanco, IF; Jimenez, MC; Perez, AE; Novoa, JML;
Indirizzi:
Hosp Clin Univ, Serv Med Interne 3, Dept Med, E-37007 Salamanca, Spain Hosp Clin Univ Salamanca Spain E-37007 ept Med, E-37007 Salamanca, Spain Univ Salamanca, Dept Fisiol & Farmacol, E-37008 Salamanca, Spain Univ Salamanca Salamanca Spain E-37008 armacol, E-37008 Salamanca, Spain
Titolo Testata:
DIGESTIVE DISEASES
fascicolo: 4, volume: 17, anno: 1999,
pagine: 235 - 240
SICI:
0257-2753(1999)17:4<235:RFICHC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER-CIRRHOSIS; HYPERDYNAMIC CIRCULATION; ALCOHOLIC CIRRHOSIS; WATER-RETENTION; CHILD-A; RATS; OXIDE; VASODILATION; HYPERFILTRATION; FILTRATION;
Keywords:
cirrhosis; renal function; nitric oxide; cyclic guanosine monophosphate; glomerular filtration rate; effective renal plasma flow; renal function reserve; renal venous resistance; filtration fraction; renin; aldosterone; amino acid-induced glomerular hyperfiltration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Rodriguez, AS Hosp Clin Univ, Serv Med Interne 3, Dept Med, Pso San Vicente 58-182, E-37007 Salamanca, Spain Hosp Clin Univ Pso San Vicente 58-182 Salamanca Spain E-37007
Citazione:
A.S. Rodriguez et al., "Renal function in compensated hepatic cirrhosis: Effects of an amino acid infusion and relationship with nitric acid", DIGEST DIS, 17(4), 1999, pp. 235-240

Abstract

Aims: In order to assess the possible participation of nitric oxide (NO) in renal function during compensated hepatic cirrhosis, we studied renal function, the plasma and urinary levels of cGMP and the concentration of nitrates and nitrites, as markers of NO synthesis in blood and urine, in 10 patients with Child A hepatic cirrhosis as compared with 10 control subjects, both under basal conditions and during stimulation (amino acid-induced glomerular hyperfiltration). Methods: To study renal function, the glomerular filtration rate (GFR), effective renal plasma flow (ERPF), renal functional reserve (RFR), renal venous resistance (RVR) and the filtration fraction (FF) were measured. Renin and aldosterone levels were determined to assess thepossible involvement of these compounds in the renin-angiotensin-aldosterone axis. Results: GFR and ERPF were significantly lower in the patients with cirrhosis than in the controls (mean GFR: 82+/-12.3 vs. 105+/-15 ml/min, p = 0.01; ERPF 452+/-86 vs. 543+/-56 ml/min, p = 6.662). The RFR value was similar in both groups. In the basal situation cGMP levels were higher in plasma and urine in patients with cirrhosis than in the controls (plasma cGMP in cirrhosis 8.4+/-2.4 vs. 4.2+/-3.5 pmol/ml; urine cGMP in cirrhosis 1.2/-2.1 vs. 0.68+/-0.1 pmol/ml). The NO levels were also higher in plasma and urine in patients with cirrhosis vs. controls (plasma NO in cirrhosis 45.5+/-9.2 vs. 30.3+/-1.2 mu mol/l; urinary NO in cirrhosis 6.2+/-1.3 vs. 3.1+/-2.3 mu mol/ml). In both groups the amino acid perfusion increased GFR, ERPF, cGMP and NO levels in plasma and urine. In the patients with cirrhosis the RVR decreased significantly during perfusion and no noteworthy changes in FF were observed. The GFR values observed during amino acid perfusion were similar in patients with cirrhosis and portal hypertension to those observed in the controls (27.2+/-12 vs. 25.3+/-16%). However, the changes induced the ERPF were more marked in patients with cirrhosis (cirrhosis 35.3+/-15 vs. 22.2+/-13%, p = 0.02). Conclusions: The present findings point to certain alterations in renal function in patients with hepatic cirrhosis and portal hypertension without ascitis, a clear difference being visible between the ERPF and GFR following amino acid-induced stimulation. The significant elevation in cGMP and NO levels in plasma and urine implies a maintained vasodilatory action that may at least partly compensate the vasoconstrictoreffects of angiotensin II. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 12:58:22