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Titolo:
Activation of synoviocytes
Autore:
Muller-Ladner, U; Gay, RE; Gay, S;
Indirizzi:
Univ Regensburg, Dept Internal Med 1, D-93042 Regensburg, Germany Univ Regensburg Regensburg Germany D-93042 , D-93042 Regensburg, Germany Univ Hosp, Dept Rheumatol, WHO, Collaborating Ctr Mol Biol & Novel Therapeut Stra, Zurich, Switzerland Univ Hosp Zurich Switzerland Novel Therapeut Stra, Zurich, Switzerland
Titolo Testata:
CURRENT OPINION IN RHEUMATOLOGY
fascicolo: 3, volume: 12, anno: 2000,
pagine: 186 - 194
SICI:
1040-8711(200005)12:3<186:AOS>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; RHEUMATOID-ARTHRITIS; SYNOVIAL FIBROBLASTS; CELLS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
83
Recensione:
Indirizzi per estratti:
Indirizzo: Muller-Ladner, U Univ Regensburg, Dept Internal Med 1, Franz Josef Str Allee 11, D-93042 Regensburg, Germany Univ Regensburg Franz Josef Str Allee 11Regensburg Germany D-93042
Citazione:
U. Muller-Ladner et al., "Activation of synoviocytes", CURR OP RH, 12(3), 2000, pp. 186-194

Abstract

The evaluation of molecular pathways has revealed various novel insights into rheumatoid arthritis pathophysiology during the past year. in addition,there is an increasing tendency toward analysis not merely of a single mechanism but rather of data addressing a substantial part of the cascade of events leading to cellular activation. Because synovial fibroblasts are key cells involved in joint destruction, this review outlines the events that trigger or inhibit the crucial pathways leading to their aggressive behavior. Major topics include cellular and humoral interactions (frequently modulated by cytokines), intracellular signaling and upregulation of gene transcription, and the deleterious effects on articular homeostasis. Curr Opin Rheumatol 2000. 12:186-194 (C) 2000 Lippincott Williams & Wilkins, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:25:53