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Titolo:
Multiple chemical sensitivity: Potential role for neural sensitization
Autore:
Sorg, BA;
Indirizzi:
Washington State Univ, Dept Vet & Comparat Anat Pharmacol & Physiol, Program Neurosci, Pullman, WA 99164 USA Washington State Univ Pullman WA USA 99164 eurosci, Pullman, WA 99164 USA
Titolo Testata:
CRITICAL REVIEWS IN NEUROBIOLOGY
fascicolo: 3, volume: 13, anno: 1999,
pagine: 283 - 316
SICI:
0892-0915(1999)13:3<283:MCSPRF>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
TIME-DEPENDENT SENSITIZATION; CHRONIC FATIGUE SYNDROME; PITUITARY-ADRENAL AXIS; SICK-BUILDING SYNDROME; POSTTRAUMATIC STRESS DISORDERS; SPINOTHALAMIC TRACT NEURONS; MEDIATED LOCOMOTOR-ACTIVITY; ORGANIC-SOLVENT EXPOSURE; SELF-REPORTED ILLNESS; PROTEIN-KINASE-C;
Keywords:
chemical intolerance; multiple chemical sensitivity; sensitization; mesolimbic dopamine; conditioned fear; avoidance; Gulf War Syndrome;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
314
Recensione:
Indirizzi per estratti:
Indirizzo: Sorg, BA Washington State Univ, Dept Vet & Comparat Anat Pharmacol & Physiol, Program Neurosci, Pullman, WA 99164 USA Washington State Univ Pullman WA USA 99164 Pullman, WA 99164 USA
Citazione:
B.A. Sorg, "Multiple chemical sensitivity: Potential role for neural sensitization", CR R NEUR, 13(3), 1999, pp. 283-316

Abstract

An emerging issue in environmental health is the phenomenon of multiple chemical sensitivity (MCS). Multiple chemical sensitivity is a controversial disorder characterized by multiorgan symptoms in response to low-level chemical exposures that are considered safe for the general population. The onset of MCS is often attributed to prior repeated chemical exposures in the home and/or workplace, and, once initiated, symptoms are triggered by extremely low levels of many chemicals/foods. No single case definition exists for MCS due to several issues that call into question its validity as a distinct illness induced by prior chemical exposure. Hypotheses regarding the etiological basis for MCS range from direct toxicological effects of chemicals to the notion that MCS is purely a psychological "belief system". One leading hypothesis suggests that MCS represents a neural sensitization phenomenon, wherein susceptible individuals demonstrate extreme sensitivity to chemicals and odor intolerance due to central nervous system (CNS) sensitization processes. The recent development of an animal model for MCS provides some support for the sensitization hypothesis and may offer evidence for behavioral changes observed in at least a subset of those reporting MCS.

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Documento generato il 27/01/21 alle ore 02:01:14