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Titolo:
Sildenafil in the treatment of sexual dysfunction induced by selective serotonin reuptake inhibitors - An overview
Autore:
Nurnberg, HG; Hensley, PL; Lauriello, J;
Indirizzi:
Univ New Mexico, Hlth Sci Ctr, Sch Med, Dept Psychiat, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 chiat, Albuquerque, NM 87131 USA
Titolo Testata:
CNS DRUGS
fascicolo: 5, volume: 13, anno: 2000,
pagine: 321 - 335
SICI:
1172-7047(200005)13:5<321:SITTOS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERECTILE DYSFUNCTION; ANTIDEPRESSANT MEDICATION; INDUCED ANORGASMIA; DEPRESSED-PATIENTS; PENILE ERECTION; DOUBLE-BLIND; MYOCARDIAL-INFARCTION; SSRI ANTIDEPRESSANTS; MAJOR DEPRESSION; ORAL SILDENAFIL;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
102
Recensione:
Indirizzi per estratti:
Indirizzo: Nurnberg, HG Univ New Mexico, Hlth Sci Ctr, Mental Hlth Ctr, 2600 Marble Ave NE, Albuquerque, NM 87131 USA Univ New Mexico 2600 Marble Ave NE Albuquerque NM USA 87131 A
Citazione:
H.G. Nurnberg et al., "Sildenafil in the treatment of sexual dysfunction induced by selective serotonin reuptake inhibitors - An overview", CNS DRUGS, 13(5), 2000, pp. 321-335

Abstract

This review discusses the potential role of sildenafil in managing antidepressant-induced sexual dysfunction, with a focus on that associated with selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SSRIs). To provide a context, the epidemiology, assessment, prevalence with comparative agents and management strategies for SSRI/antidepressant-induced sexual dysfunction are reviewed. Sexual dysfunction is a frequent adverse effect of many therapeutic agents; it is prominently associated with SSRIs, and may be an important factor contributing to discontinuation of and noncompliance with antidepressants. However, a significant number of patients spontaneously develop tolerance tothis reversible adverse effect over time. Sildenafil is an important addition to the therapeutic armamentarium for treating erectile dysfunction in men. Preliminary data suggest that it also has potential for treating antidepressant-induced sexual dysfunction in menand women, particularly in patients who do not have sexual dysfunction prior to becoming ill. The effective management of SSRI treatment emergent sexual dysfunction can have an important impact on improving the effectivenessand clinical outcomes of treatment by reducing switching and premature discontinuation of medication, and reducing the related morbidity/mortality ofmajor depression and other disorders for which these drugs are prescribed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:40:59