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Titolo:
The effect of chronic clonidine administration on salivary glands and caries in the rat
Autore:
Watson, GE; Pearson, SK; Bowen, WH;
Indirizzi:
Univ Rochester, Eastman Dept Dent, Rochester, NY USA Univ Rochester Rochester NY USA er, Eastman Dept Dent, Rochester, NY USA Univ Rochester, Dept Physiol & Pharmacol, Rochester, NY USA Univ Rochester Rochester NY USA t Physiol & Pharmacol, Rochester, NY USA Univ Rochester, Ctr Oral Biol, Rochester, NY USA Univ Rochester RochesterNY USA hester, Ctr Oral Biol, Rochester, NY USA Univ Rochester, Dept Microbiol & Immunol, Rochester, NY USA Univ Rochester Rochester NY USA t Microbiol & Immunol, Rochester, NY USA Univ Rochester, Dept Environm Hlth, Rochester, NY USA Univ Rochester Rochester NY USA r, Dept Environm Hlth, Rochester, NY USA
Titolo Testata:
CARIES RESEARCH
fascicolo: 2, volume: 34, anno: 2000,
pagine: 194 - 200
SICI:
0008-6568(200003/04)34:2<194:TEOCCA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBMANDIBULAR GLANDS; WITHDRAWAL SYMPTOMS; SECRETION; PILOCARPINE; PHARMACOKINETICS; HYPERTENSION; INFUSION; PROTEIN; FLOW;
Keywords:
animals; attention deficit hyperactivity disorder; clonidine; saliva; salivary glands;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Watson, GE 601 Elmwood Ave,Box 611, Rochester, NY 14642 USA 601 Elmwood Ave,Box 611 Rochester NY USA 14642 r, NY 14642 USA
Citazione:
G.E. Watson et al., "The effect of chronic clonidine administration on salivary glands and caries in the rat", CARIES RES, 34(2), 2000, pp. 194-200

Abstract

Clonidine is a widely prescribed, centrally acting antihypertensive with proposed pharmacologic mechanisms of stimulation of central postsynaptic alpha(2)-adrenergic receptors and agonist activity at presynaptic alpha(2)-adrenergic receptors, interfering with peripheral regulation of norepinephrineand acetylcholine release. Both of these mechanisms are capable of adversely influencing salivary output and composition, potentially leaving an individual with increased caries risk. The purpose of the present study was to determine the effect of chronic administration of clonidine on saliva, salivary glands, and caries in rats. Sprague-Dawley rat pups were infected withStreptococcus sobrinus, given Diet 2000 and 10% sucrose water ad libitum, and either desalivated, or treated with clonidine HCl (125 or 250 mu g/kg administered daily for 28 days by means of osmotic minipumps), or assigned as controls. There were no statistical differences in stimulated parotid or submandibular gland salivary output or sublingual gland weights among the groups. The weight of the submandibular glands as a percent of total body weight was significantly decreased in animals that received clonidine when compared with controls. Sulcal caries scores in both clonidine groups and smooth surface caries scores in the high clonidine group were increased when compared with control animals. Positive control animals (desalivated) had significantly higher caries scores than all other groups. These data show that chronic administration of clonidine significantly decreases submandibulargland weight and increases susceptibility to dental caries. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:42:15