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Titolo:
Diminished central fatigue by inhibition of the L-system transporter for the uptake of tryptophan
Autore:
Yamamoto, T; Newsholme, EA;
Indirizzi:
Tezukayama Univ, Hlth Sci Lab, Nara 6318501, Japan Tezukayama Univ Nara Japan 6318501 iv, Hlth Sci Lab, Nara 6318501, Japan Univ Dept Biochem, Oxford, England Univ Dept Biochem Oxford EnglandUniv Dept Biochem, Oxford, England
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 1, volume: 52, anno: 2000,
pagine: 35 - 38
SICI:
0361-9230(20000501)52:1<35:DCFBIO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID TRANSPORT; BLOOD-BRAIN-BARRIER; RAT; METABOLISM; SEROTONIN; EXERCISE;
Keywords:
free tryptophan; branched chain amino acids; L-system transporter; central fatigue; synaptosomes; nagase analbuminemic rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Yamamoto, T Tezukayama Univ, Hlth Sci Lab, Tezukayama 7-1-1, Nara 6318501,Japan Tezukayama Univ Tezukayama 7-1-1 Nara Japan 6318501 01, Japan
Citazione:
T. Yamamoto e E.A. Newsholme, "Diminished central fatigue by inhibition of the L-system transporter for the uptake of tryptophan", BRAIN RES B, 52(1), 2000, pp. 35-38

Abstract

Nagase genetically analbuminemic rats (NAR) were run to fatigue. Administration of branched chain amino acids (BCAA) before exhaustive exercise, resulted in a post-fatigue decreased tryptophan uptake (-22%, p < 0.05) and 5-hydroxytryptophan (5-HTP) uptake (-29%, p < 0.01) into the synaptosomes isolated from the striatum when compared with saline administration. At the same time, NAR who received either BCAA or 2-aminobicyclo[2,2,1]heptane-2-carboxylic acid (BCH, a specific inhibitor for the L-system transporter) had a considerably prolonged run time to exhaustion (by twofold), compared to those who received either saline or albumin treatments. When classified by runtime, it was of interest that, when the data for BCAA and BCH treatments for the longer run time NAR (Group B) was combined, it gave rise to a significant decrease in synaptosomal tryptophan and 5-HTP of a similar magnitude to that observed with BCAA alone. These levels were lower than those observed in NAR in the shorter run time group (Group A) for all treatments. Theseresults support the view that an activated serotonergic function may be involved in central fatigue, which can be diminished by inhibition of the L-system transporter. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 07:06:54