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Titolo:
Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load
Autore:
Aarts, WM; Bende, RJ; Steenbergen, EJ; Kluin, PM; Ooms, ECM; Pals, ST; van Noesel, CJM;
Indirizzi:
Univ Amsterdam, Acad Med Ctr, Dept Pathol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands St Radboud Hosp, Dept Pathol, Nijmegen, Netherlands St Radboud Hosp Nijmegen Netherlands Dept Pathol, Nijmegen, Netherlands Leiden Univ, Med Ctr, Dept Pathol, Leiden, Netherlands Leiden Univ Leiden Netherlands ed Ctr, Dept Pathol, Leiden, Netherlands Westeinde Hosp, Dept Pathol, The Hague, Netherlands Westeinde Hosp The Hague Netherlands ept Pathol, The Hague, Netherlands
Titolo Testata:
BLOOD
fascicolo: 9, volume: 95, anno: 2000,
pagine: 2922 - 2929
SICI:
0006-4971(20000501)95:9<2922:VHCGAO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-HODGKINS-LYMPHOMA; MEMORY B-CELLS; V-H GENES; IMMUNOGLOBULIN GENES; REGION GENES; ANTIGEN SELECTION; TUMOR PROGRESSION; GERMINAL CENTER; HYPERMUTATION; T(14-18);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: van Noesel, CJM Univ Amsterdam, Acad Med Ctr, Dept Pathol, Meibergdreef 9,NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Meibergdreef 9 AmsterdamNetherlands NL-1105 AZ
Citazione:
W.M. Aarts et al., "Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load", BLOOD, 95(9), 2000, pp. 2922-2929

Abstract

The expansion of follicular lymphomas (FLs) resembles, both morphologically and functionally, normal germinal center B-cell growth. The tumor cells proliferate in networks of follicular dendritic cells and are believed to becapable of somatic hypermutation and isotype switching. To investigate therelation between somatic mutation and heavy chain isotype expression, we analyzed the variable heavy (V-H) chain genes of 30 FL samples of different isotypes, The V-H genes of the FLs were heavily mutated (29.3 mutations on average). In addition, isotype-switched lymphomas contained more somatic mutations than immunoglobulin M-positive lymphomas (33.8 mutations per V-H gene versus 23.0, respectively). In all but one of the FLs, the ratios of replacement versus silent mutations in the framework regions were low, independent of the absolute number of somatic mutations and the level of intraclonal variation. Analysis of relapse samples of 4 FLs showed no obvious increase in somatic mutation toad in most FLs and a decrease in intraclonal variation in time. In 3 of 4 cases, we obtained evidence for selection of certain subclones, rather than clonal evolution. Our findings question if intraclonal variation is always a reflection of ongoing somatic hypermutation, This may have implications for the concept of antigen-driven lymphomagenesis, (Blood, 2000;95:2922-2929) (C) 2000 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 00:47:23