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Titolo:
Nitric oxide synthase in the rabbit uterus and vagina: Hormonal regulationand functional significance
Autore:
Al-Hijji, J; Larsson, B; Batra, S;
Indirizzi:
Univ Lund Hosp, Dept Obstet & Gynecol, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 tet & Gynecol, SE-22185 Lund, Sweden Univ Lund Hosp, Dept Clin Pharmacol, SE-22185 Lund, Sweden Univ Lund HospLund Sweden SE-22185 lin Pharmacol, SE-22185 Lund, Sweden
Titolo Testata:
BIOLOGY OF REPRODUCTION
fascicolo: 5, volume: 62, anno: 2000,
pagine: 1387 - 1392
SICI:
0006-3363(200005)62:5<1387:NOSITR>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOWN-REGULATION; NONPREGNANT SHEEP; ESTROGEN; EXPRESSION; PREGNANCY; TRACT; PROGESTERONE; LOCALIZATION; PARTURITION; MYOMETRIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Batra, S Univ Lund Hosp, Dept Obstet & Gynecol, SE-22185 Lund, Sweden UnivLund Hosp Lund Sweden SE-22185 ecol, SE-22185 Lund, Sweden
Citazione:
J. Al-Hijji et al., "Nitric oxide synthase in the rabbit uterus and vagina: Hormonal regulationand functional significance", BIOL REPROD, 62(5), 2000, pp. 1387-1392

Abstract

The effects of estrogen (E-2), progesterone (P-4), and E-2 and P-4 (E-2+P-4) on uterine, vaginal, and cerebellar nitric oxide synthase (NOS) were examined. Additionally, experiments were done to investigate whether NOS-containing nerves were present in the uterus and vagina and the extent to which vaginal smooth muscle response was dependent on nitric oxide (NO). Cytosolic NOS was determined by the formation of [C-14]citrulline from [C-14]arginine, and NOS localization was visualized by immunohistochemistry. Vaginal smooth muscle relaxation was induced by electrical field stimulations (EFS). NOS activity in the uterus was markedly down-regulated in all hormone-treated groups. Vaginal NOS activity was nearly 4-fold higher than the uterine NOS activity and was considerably reduced by E-2 or E-2+P-4 treatment. In contrast to findings in the uterus, P-4 treatment up-regulated vaginal NOS. Hormone treatment had no significant effect on cerebellar NOS. NOS-containing nerves could be demonstrated in the uterus and vagina by immunohistochemistry. Vaginal smooth muscle responded with relaxation after EFS, which was inhibited by N-G-nitro-L-arginine. A relatively high vaginal NOS, a down-regulation by E-2, an up-regulation by P-4, and NO-dependent response of vaginal smooth muscle suggest a tissue-specific physiological role.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:18:26