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Titolo:
Expression of functional granulocyte colony-stimulating factor receptors on human B-lymphocytic leukemia cells
Autore:
Handa, A; Kashimura, T; Takeuchi, S; Yamamoto, A; Murohashi, I; Bessho, M; Hirashima, K;
Indirizzi:
Saitama Med Sch, Dept Internal Med 1, Moroyama, Saitama 3500451, Japan Saitama Med Sch Moroyama Saitama Japan 3500451 ma, Saitama 3500451, Japan
Titolo Testata:
ANNALS OF HEMATOLOGY
fascicolo: 3, volume: 79, anno: 2000,
pagine: 127 - 131
SICI:
0939-5555(200003)79:3<127:EOFGCF>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE LYMPHOBLASTIC-LEUKEMIA; FACTOR G-CSF; PROLIFERATIVE RESPONSE; CD34 EXPRESSION; DIFFERENTIATION; CHEMOTHERAPY; TRANSLOCATIONS; INTERLEUKIN-3; APOPTOSIS; LYMPHOMA;
Keywords:
G-CSF; G-CSF receptor; B-lymphocytic leukemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Handa, A NHLBI, Hematol Branch, NIH, Bldg 10 Rm 7C 218,9000 Rockville Pike, Bethesda, MD 20892 USA NHLBI Bldg 10 Rm 7C 218,9000 Rockville Pike Bethesda MD USA 20892
Citazione:
A. Handa et al., "Expression of functional granulocyte colony-stimulating factor receptors on human B-lymphocytic leukemia cells", ANN HEMATOL, 79(3), 2000, pp. 127-131

Abstract

We analyzed the expression of cell surface antigens and granulocyte colony-stimulating factor (G-CSF) receptors using flow cytometry, the expression of G-CSF mRNA receptor, using reverse transcription (RT)-PCR, and tested the effect of G-CSF on leukemia colony formation. A total of 14 lymphocytic leukemia patients were examined, seven with acute lymphocytic leukemia (ALL), two with adult T-cell leukemia (ATL), two with B-chronic lymphocytic leukemia (CLL), two with chronic myelocytic leukemia in lymphoid blastic crisis(CML-LBC), and one with plasma cell leukemia (PCL). The presence of G-CSF receptors was demonstrated in 4/14 (29%) patients, two with ALL, one with CLL, and one with CML-LBC, and was associated with stimulation of leukemia clonogenic cell growth by G-CSF. In addition, all four positive leukemia cell types expressed typical B-cell antigens, Our results indicated that G-CSFreceptors are expressed on some portion of B-lymphoid leukemia and that their receptors are functional as growth stimulators.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:57:59