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Titolo:
Skeletal muscle dysfunction in chronic obstructive pulmonary disease and chronic heart failure: underlying mechanisms and therapy perspectives
Autore:
Gosker, HR; Wouters, EFM; van der Vusse, GJ; Schols, AMWJ;
Indirizzi:
Maastricht Unit, Dept Pulmonol, Maastricht, Netherlands Maastricht Unit Maastricht Netherlands ulmonol, Maastricht, Netherlands Maastricht Unit, Dept Physiol, Maastricht, Netherlands Maastricht Unit Maastricht Netherlands Physiol, Maastricht, Netherlands
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 5, volume: 71, anno: 2000,
pagine: 1033 - 1047
SICI:
0002-9165(200005)71:5<1033:SMDICO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; AIR-FLOW LIMITATION; RESTING ENERGY-EXPENDITURE; MYOSIN HEAVY-CHAIN; CHRONIC RESPIRATORY-FAILURE; ANOREXIA-NERVOSA PATIENTS; STEROID-INDUCED MYOPATHY; CHRONIC CARDIAC-FAILURE; FIBER-TYPE COMPOSITION; RAT SOLEUS MUSCLE;
Keywords:
chronic obstructive pulmonary disease; COPD; chronic heart failure; CHF; skeletal muscle; peripheral muscle; respiratory muscle; exercise intolerance; muscle performance; muscle morphology; muscle metabolism; hypoxia; oxidative stress; medication; disuse; nutritional depletion; systemic inflammation; oxygen therapy; antioxidant status; training; nutritional support; anabolic steroids; review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
236
Recensione:
Indirizzi per estratti:
Indirizzo: Gosker, HR Univ Hosp Maastricht, Dept Pulmonol, POB 5800, NL-6202 AZ Maastricht, Netherlands Univ Hosp Maastricht POB 5800 Maastricht Netherlands NL-6202 AZ
Citazione:
H.R. Gosker et al., "Skeletal muscle dysfunction in chronic obstructive pulmonary disease and chronic heart failure: underlying mechanisms and therapy perspectives", AM J CLIN N, 71(5), 2000, pp. 1033-1047

Abstract

Low exercise tolerance has a large influence on health status in chronic obstructive pulmonary disease and chronic heart failure. In addition to primary organ dysfunction, impaired skeletal muscle performance is a strong predictor of low exercise capacity. There are striking similarities between both disorders with respect to the muscular alterations underlying the impairment. However, different alterations occur in different muscle types. Histologic and metabolic data show that peripheral muscles undergo a shift from oxidative to glycolytic energy metabolism, whereas the opposite is observedin the diaphragm. These Endings are in line with the notion that peripheral and diaphragm muscle are limited mainly by endurance and strength capacity, respectively. In both diseases,. muscular impairment is multifactoriallydetermined; hypoxia, oxidative stress, disuse, medication, nutritional depletion, and systemic inflammation may contribute to the observed muscle abnormalities and each factor has its own potential for innovative treatment approaches.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 17:15:34