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Titolo:
Aerosolized surfactant in lung-lavaged adult rats: factors influencing thetherapeutic response
Autore:
Bahlmann, H; Sun, B; Nilsson, G; Curstedt, T; Robertson, B;
Indirizzi:
Karolinska Inst, Div Expt Perinatal Pathol, Dept Woman & Child Hlth, S-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17176 Hlth, S-17176 Stockholm, Sweden Karolinska Hosp, Dept Clin Chem, S-10401 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-10401 Chem, S-10401 Stockholm, Sweden
Titolo Testata:
ACTA ANAESTHESIOLOGICA SCANDINAVICA
fascicolo: 5, volume: 44, anno: 2000,
pagine: 612 - 622
SICI:
0001-5172(200005)44:5<612:ASILAR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; INSTILLED EXOGENOUS SURFACTANT; NATURAL SURFACTANT; NONUNIFORM PATTERN; PRETERM LAMBS; GAS-EXCHANGE; ANIMAL-MODEL; INJURY; VENTILATION; REPLACEMENT;
Keywords:
pulmonary surfactants; aerosols; rats; respiratory distress syndrome; bronchoalveolar lavage fluid; capillary permeability; albumins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Robertson, B Karolinska Inst, Div Expt Perinatal Pathol, Dept Woman & Child Hlth, L7-03, S-17176 Stockholm, Sweden Karolinska Inst L7-03 Stockholm Sweden S-17176 kholm, Sweden
Citazione:
H. Bahlmann et al., "Aerosolized surfactant in lung-lavaged adult rats: factors influencing thetherapeutic response", ACT ANAE SC, 44(5), 2000, pp. 612-622

Abstract

Objective: To evaluate the effect of aerosolized modified natural surfactant in adult rats with respiratory failure. Methods: Lung-lavaged adult rats were treated with aerosolized surfactant,aerosolized saline or a bolus of surfactant. Surfactant was labelled with dimyristoylphosphatidylcholine (DMPC) and human serum albumin was given intravenously for evaluation of lung protein leakage. Blood gases and dynamic compliance were measured intermittently At the end of ventilation, the lungs were either fixed by vascular perfusion for histological examination or washed for determination of total phospholipids, DMPC and human albumin in the lavage fluid. Results: Treatment with bolus surfactant led to a quick and sustained restoration of pre-lavage blood gas values in most animals. The response to aerosolized surfactant varied considerably, with an overall moderate improvement of gas exchange. The saline-treated group failed to show any significantrecovery of lung function. No histopathological differences were found between any of the groups. On average 0.46% of total administered aerosolized surfactant could be recovered. Vascular-to-alveolar leakage of human albumin averaged 11%, with no significant differences between the groups. Final values fur PaO2 were significantly correlated with total phospholipids in the lavage fluid, and inversely related to the vascular-to-alveolar leakage of albumin. Conclusion: Neither bolus nor aerosolized surfactant influenced lung morphology. Nebulized surfactant improved lung function but the effect was inferior to that obtained with bolus surfactant, and the outcome depended on thebalance between the combined pool size of exogenous and endogenous surfactant and the vascular-to-alveolar leakage of serum protein. (C) Acta Anaesthesiologica Scandinavica 44 (2000).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 21:48:22