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Titolo:
The CD2-subset of the Ig superfamily of cell surface molecules: receptor-ligand pairs expressed by NK cells and other immune cells
Autore:
Tangye, SG; Phillips, JH; Lanier, LL;
Indirizzi:
DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunobiol, Palo Alto, CA 94304 USA DNAX Res Inst Mol & Cellular Biol Inc Palo Alto CA USA 94304 CA 94304 USA Univ Sydney, Centenary Inst Canc Med & Cell Biol, Immune Regulat Grp, Sydney, NSW 2042, Australia Univ Sydney Sydney NSW Australia 2042 at Grp, Sydney, NSW 2042, Australia
Titolo Testata:
SEMINARS IN IMMUNOLOGY
fascicolo: 2, volume: 12, anno: 2000,
pagine: 149 - 157
SICI:
1044-5323(200004)12:2<149:TCOTIS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; LINKED LYMPHOPROLIFERATIVE SYNDROME; LYMPHOCYTIC ACTIVATION MOLECULE; PROTEIN TYROSINE KINASES; HUMAN B-LYMPHOCYTES; T-CELLS; COUNTER-RECEPTOR; IMMUNOGLOBULIN SUPERFAMILY; ERYTHROCYTE RECEPTOR; CYTOPLASMIC DOMAIN;
Keywords:
CD2; NK cells; SAP; T cells; X-linked lymphoproliferative syndrome;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Tangye, SG DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunobiol, 901 Calif Ave, Palo Alto, CA 94304 USA DNAX Res Inst Mol & Cellular Biol Inc 901 Calif Ave Palo Alto CA USA 94304
Citazione:
S.G. Tangye et al., "The CD2-subset of the Ig superfamily of cell surface molecules: receptor-ligand pairs expressed by NK cells and other immune cells", SEMIN IMMUN, 12(2), 2000, pp. 149-157

Abstract

The CD2-subset of the immunoglobulin superfamily of cell surface receptorsis an emerging family of proteins involved in cellular activation. Membersof this family are CD2, CD48, CD58, CD84, signaling lymphocytic activationmolecule (SLAM), 2B4 and Ly-9. These proteins are expressed on different leukocyte populations and the receptors of this family, specifically CD2, 2B4 and SLAM, contribute to the activation of T cells and natural killer cells. 2B4 and SLAM associate with a protein termed SLAM-associated protein that is the genetic defect in the immunodeficiency X-linked lymphoproliferative syndrome. Impaired signaling via these receptors may contribute to this often-fatal immunodeficiency.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:29:46