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Titolo:
Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice
Autore:
Ishii, S; Shimizu, T;
Indirizzi:
Univ Tokyo, Fac Med, Dept Biochem & Mol Biol, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 Mol Biol, Bunkyo Ku, Tokyo 1130033, Japan
Titolo Testata:
PROGRESS IN LIPID RESEARCH
fascicolo: 1, volume: 39, anno: 2000,
pagine: 41 - 82
SICI:
0163-7827(200001)39:1<41:PF(RAG>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; MOUSE PREIMPLANTATION EMBRYOS; INDUCED ASTHMATIC RESPONSES; HUMAN-ENDOTHELIAL-CELLS; LONG-TERM POTENTIATION; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; HAMSTER OVARY CELLS; INDUCED BRONCHIAL HYPERRESPONSIVENESS; GLYCERYL ETHER PHOSPHORYLCHOLINE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
367
Recensione:
Indirizzi per estratti:
Indirizzo: Ishii, S Univ Tokyo, Fac Med, Dept Biochem & Mol Biol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 1130033 Tokyo 1130033, Japan
Citazione:
S. Ishii e T. Shimizu, "Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice", PROG LIPID, 39(1), 2000, pp. 41-82

Abstract

Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a biologically active phospholipid: mediator. Although PAF was initially recognized for its potential to induce platelet aggregation and secretion, intense investigations have elucidated potent biological actions ofPAF in a broad range of cell types and tissues, many of which also producethe molecule. PAF acts by binding to a unique G-protein-coupled seven transmembrane receptor. PAF receptor is linked to intracellular signal transduction pathways, including turnover of phosphatidylinositol, elevation in intracellular calcium concentration, and activation of kinases, resulting in versatile bioactions, On the basis of numerous pharmacological reports, PAF is thought to have many pathophysiological and physiological functions. Recently advanced molecular technics enable us not only to clone PAF receptor cDNAs and genes, but also generate PAF receptor mutant animals, i.e., PAF receptor-overexpressing mouse and PAF receptor-deficient mouse. These mutantmice gave us a novel ana specific approach for identifying the pathophysiological and physiological functions of PAF. This review also describes the phenotypes of these mutant mice and discusses them by referring to previously reported pharmacological and genetical data. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 16:10:29