Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The NMDA antagonist EAA 494 does not impair working memory in an operant DNMTP task in rats
Autore:
Ballard, TM; McAllister, KH;
Indirizzi:
Novartis Pharma Inc, Nervous Syst Dept, CH-4002 Basel, Switzerland Novartis Pharma Inc Basel Switzerland CH-4002 CH-4002 Basel, Switzerland
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 4, volume: 65, anno: 2000,
pagine: 725 - 730
SICI:
0091-3057(200004)65:4<725:TNAE4D>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; RECEPTOR ANTAGONIST; CHOLINERGIC DRUGS; PERFORMANCE; CPP; MK-801; SDZ-EAA-494; SCOPOLAMINE; AP5;
Keywords:
delayed nonmatching-to-position task; working memory; mediating behavior; EAA494 NMDA antagonist; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: McAllister, KH Novartis Pharma Inc, Nervous Syst Dept, WSJ-386-226, CH-4002 Basel, Switzerland Novartis Pharma Inc WSJ-386-226 Basel Switzerland CH-4002
Citazione:
T.M. Ballard e K.H. McAllister, "The NMDA antagonist EAA 494 does not impair working memory in an operant DNMTP task in rats", PHARM BIO B, 65(4), 2000, pp. 725-730

Abstract

There is contrasting evidence for an impairment of spatial working memory in operant delayed matching/or nonmatching to position (DMTP/DNMTP) tasks, as both delay-dependent and -independent disruption of choice accuracy has been found following N-methyl-D-aspartate (NMDA) receptor blockade. Using awithin-subjects experimental design, the effect of the competitive NMDA receptor antagonist, EAA 494 (D-CPP-ene) (1, 1.5, 2 mg/kg IP 30 min prior), on working memory was investigated in male Lister Hooded rats pretrained to the DNMTP task (0-16-s delay in intervals). Metal barriers were inserted between the food magazine and levers to inhibit the use of mediating strategies, such as orientation towards the correct lever during the delay interval, because this behavior may contribute to the delay-dependent disruption noted in previous studies. It was found that EAA 494 did not modify working memory either in the presence or absence of barriers. However, a dose-dependent impairment of task performance was recorded, notably in the presence ofbarriers. These results indicate that competitive blockade of NMDA receptors with EAA 494 does not result in impaired working memory in rats and parallel the lack of effect of the compound upon working memory in humans. Activation of NMDA receptors does not appear to be essential for the performance of spatial tasks requiring working memory. (C) 2000 Elsevier Science.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:29:35