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Titolo:
Effect of subchronic antidepressant treatments on behavioral, neurochemical, and endocrine changes in the forced-swim test
Autore:
Connor, TJ; Kelliher, P; Shen, Y; Harkin, A; Kelly, JP; Leonard, BE;
Indirizzi:
Natl Univ Ireland Univ Coll Galway, Dept Pharmacol, Galway, Ireland Natl Univ Ireland Univ Coll Galway Galway Ireland acol, Galway, Ireland
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 4, volume: 65, anno: 2000,
pagine: 591 - 597
SICI:
0091-3057(200004)65:4<591:EOSATO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM TREATMENT; RAT-BRAIN; ANIMAL-MODELS; DESIPRAMINE TREATMENT; SEROTONIN METABOLISM; PSYCHOLOGICAL STRESS; IMMUNE CHANGES; VENLAFAXINE; DEPRESSION; 5-HYDROXYTRYPTAMINE;
Keywords:
amygdala; antidepressant; depression; forced-swim test; HPA axis; noradrenaline; serotonin; stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Connor, TJ Natl Univ Ireland Univ Coll Galway, Dept Pharmacol, Galway, Ireland Natl Univ Ireland Univ Coll Galway Galway Ireland y, Ireland
Citazione:
T.J. Connor et al., "Effect of subchronic antidepressant treatments on behavioral, neurochemical, and endocrine changes in the forced-swim test", PHARM BIO B, 65(4), 2000, pp. 591-597

Abstract

The purpose of the present study was to examine the effect of subchronic treatment (24 days) with antidepressants displaying differential effects on noradrenaline and serotonin reuptake, on behavior, neurochemistry and hypothalamic-pituitary-adrenal (HPA) axis activity following FST exposure in therat. Desipramine (7.5 mg/kg, IF) significantly decreased immobility in theFST, whilst paroxetine (7.5 mg/kg IF) and venlafaxine (10 mg/kg, IF) were without effect. Nonetheless, treatment with all three antidepressants significantly attenuated stress-related increases in amygdaloid and cortical serotonin turnover. Of the three antidepressants examined, only desipramine attenuated the stress-associated elevation in serum corticosterone. In conclusion, although FST-induced increases in serotonin turnover in the frontal cortex and amygdala were attenuated following treatment with all three antidepressants, FST-induced behavioral changes and increased HPA axis activity were normalized only following desipramine treatment. In addition, these results suggest that neurochemical mechanisms independent of increased serotonergic activity subserve the normalization of behavior and HPA axis responses in the FST. These data also add to our understanding of the interactionsbetween antidepressants and stress-induced behavioral, neurochemical, and endocrine alterations, and illustrates important differences between classes of antidepressants. (C) 2000 Elsevier Science Inc.

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Documento generato il 29/09/20 alle ore 03:46:36