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Titolo:
Longitudinal survey of lymphocyte subpopulations in the first year of life
Autore:
de Vries, E; de Bruin-Versteeg, S; Comans-Bitter, WM; de Groot, R; Hop, WCJ; Boerma, GJM; Lotgering, FK; van Dongen, JJM;
Indirizzi:
Erasmus Univ, Dept Immunol, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands Erasmus Univ, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands Sophia Childrens Hosp, Dept Pediat, Rotterdam, Netherlands Sophia Childrens Hosp Rotterdam Netherlands iat, Rotterdam, Netherlands Univ Rotterdam Hosp, Dept Clin Chem, Rotterdam, Netherlands Univ RotterdamHosp Rotterdam Netherlands Chem, Rotterdam, Netherlands Univ Rotterdam Hosp, Dept Obstet & Gynecol, Rotterdam, Netherlands Univ Rotterdam Hosp Rotterdam Netherlands necol, Rotterdam, Netherlands Bosch Medicentrum, Dept Pediat, Shertogenbosch, Netherlands Bosch Medicentrum Shertogenbosch Netherlands hertogenbosch, Netherlands
Titolo Testata:
PEDIATRIC RESEARCH
fascicolo: 4, volume: 47, anno: 2000,
parte:, 1
pagine: 528 - 537
SICI:
0031-3998(200004)47:4<528:LSOLSI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; HUMAN CORD BLOOD; HEALTHY INFANTS; NEONATAL BLOOD; HUMAN CD38; T-CELLS; DIFFERENTIATION; EXPRESSION; CHILDREN; SUBSETS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: de Vries, E Erasmus Univ, Dept Immunol, POB 1738, NL-3000 DR Rotterdam, Netherlands Erasmus Univ POB 1738 Rotterdam Netherlands NL-3000 DR rlands
Citazione:
E. de Vries et al., "Longitudinal survey of lymphocyte subpopulations in the first year of life", PEDIAT RES, 47(4), 2000, pp. 528-537

Abstract

Age-matched reference values for lymphocyte subpopulations are generally obtained via cross-sectional studies, whereas patients are followed longitudinally. We performed a detailed longitudinal analysis of the changes in lymphocyte subpopulations in a group of Ii healthy infants followed from birthup to 1 y of age, with special attention for early developmental markers, markers of maturation, and markers of activation. We found that T and B lymphocytes increased at 1 and 6 wk of age, respectively. In contrast, NK cells showed a sharp decline directly after birth, suggesting that they rue more important during pregnancy than thereafter. CD45RA(+)-mainly CD4(+)-naiveT lymphocytes were high at birth, and increased further during the first year of life; they form a large expanding pool of cells, ready for participation in primary immune responses. The absolute counts of CD45RO(+) memory Tlymphocytes were similar in infants and adults, albeit with a lower level of expression of CD45RO on infant T lymphocytes. Almost all infant T lymphocytes expressed CD38 throughout the first year of life. The abundant expression of CD38 on an infant's T lymphocytes might be related to a greater metabolic need of the large population of naive untriggered cells that art continually involved in primary immune responses during the first year of life. The high B lymphocyte counts in infants mainly concerned CD38(+) B lymphocytes throughout the first year of life. Also, the relative frequencies of CD1c(+) and CD5(+) B lymphocytes were higher throughout the first year of life than in adults. Therefore, CD1c, CD5, and CD38 could be markers of untriggered B lymphocytes. In conclusion, our longitudinal survey of T and B lymphocytes, NK cells, and their subpopulations during the first year of lifehelps to complete the picture of lymphocyte development in infants. This information contributes to the correct interpretation of data from infants with possible immune disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:46:13