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Titolo:
Expression of p27kip1 and p53 in medulloblastoma: Relationship with cell proliferation and survival
Autore:
Adesina, AM; Dunn, ST; Moore, WE; Nalbantoglu, J;
Indirizzi:
Univ Oklahoma, Hlth Sci Ctr, Dept Pathol, Oklahoma City, OK 73104 USA UnivOklahoma Oklahoma City OK USA 73104 hol, Oklahoma City, OK 73104 USA Univ Oklahoma, Hlth Sci Ctr, Dept Biostat & Epidemiol, Oklahoma City, OK 73104 USA Univ Oklahoma Oklahoma City OK USA 73104 iol, Oklahoma City, OK 73104 USA McGill Univ, Montreal Neurol Inst, Montreal, PQ, Canada McGill Univ Montreal PQ Canada ontreal Neurol Inst, Montreal, PQ, Canada
Titolo Testata:
PATHOLOGY RESEARCH AND PRACTICE
fascicolo: 4, volume: 196, anno: 2000,
pagine: 243 - 250
SICI:
0344-0338(2000)196:4<243:EOPAPI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT KINASE INHIBITOR; GROWTH-FACTOR-BETA; MDM2 GENE AMPLIFICATION; CYCLE ARREST; TGF-BETA; P27(KIP1) EXPRESSION; POTENTIAL MEDIATOR; CDK4 SYNTHESIS; P21; G1;
Keywords:
cyclin-dependent kinase inhibitors medulloblastoma; primitive neuroectodermal tumors; p21cip1; p27kip1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Adesina, AM Univ Oklahoma, Hlth Sci Ctr, Dept Pathol, 940 Stanton L Young Blvd,Room 451, Oklahoma City, OK 73104 USA Univ Oklahoma 940 Stanton L Young Blvd,Room 451 Oklahoma City OK USA 73104
Citazione:
A.M. Adesina et al., "Expression of p27kip1 and p53 in medulloblastoma: Relationship with cell proliferation and survival", PATH RES PR, 196(4), 2000, pp. 243-250

Abstract

p27kip1 and p21cip1 are cyclin-dependent kinase (cdk) inhibitors which along with p53 play critical roles in the control of cell cycle progression. Accumulation of p27kip1 in post-mitotic neurons is a major event of neurogenesis. We hypothesized that a dysregulation of the expression of p53 and these cdk inhibitors underlies cellular proliferation in medulloblastomas, andtested this hypothesis by investigating p27kip1, p21cip1, Bcl2 and p53 immunoreactivity in 14 medulloblastoma tumors. We noted an inverse relationship between p27kip1 expression and cellular proliferation (MIB1). Focal islands of neuroblastic or glial differentiation expressed high levels of p27kip1, while the undifferentiated, highly-proliferative population of tumor cells showed no detectable p27kip1 expression, thus suggesting a role for p27kip1 in cell cycle control in medulloblastoma. In addition, there was no detectable p21cip1 expression in any of the medulloblastomas studied. The low level of apoptosis displayed by these tumors was not associated with the expression of Bcl-2. A significant relationship was found between detection of p53 protein and poor survival. Since: p21cip1 and p27kip1 are often co-expressed with other INK4 family of cdk inhibitors during the induction of cellular differentiation and are synergistic in their effect, a deregulation of their coordinate expression may underlie the lack of complete differentiation in medulloblastoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 13:35:14