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Titolo:
Cholinergic deafferentation of the rabbit cortex: a new animal model of A beta deposition
Autore:
Beach, TG; Potter, PE; Kuo, YM; Emmerling, MR; Durham, RA; Webster, SD; Walker, DG; Sue, LI; Scott, S; Layne, KJ; Roher, AE;
Indirizzi:
Sun Hlth Res Inst, Sun City, AZ 85351 USA Sun Hlth Res Inst Sun City AZ USA 85351 Res Inst, Sun City, AZ 85351 USA Midwestern Univ, Dept Pharmacol, Glendale, AZ 85308 USA Midwestern Univ Glendale AZ USA 85308 t Pharmacol, Glendale, AZ 85308 USA Parke Davis, Ann Arbor, MI 48106 USA Parke Davis Ann Arbor MI USA 48106Parke Davis, Ann Arbor, MI 48106 USA Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 iol & Biochem, Irvine, CA 92697 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 283, anno: 2000,
pagine: 9 - 12
SICI:
0304-3940(20000331)283:1<9:CDOTRC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; ALZHEIMERS-DISEASE; BRAIN; IMMUNOTOXIN; SECRETION; PEPTIDE; FLUID;
Keywords:
amyloid angiopathy; animal model; Alzheimer's disease; cholinergic; immunotoxin; beta-amyloid precursor protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Beach, TG Sun Hlth Res Inst, 10515 W Santa Fe Dr, Sun City, AZ 85351 USA Sun Hlth Res Inst 10515 W Santa Fe Dr Sun City AZ USA 85351 USA
Citazione:
T.G. Beach et al., "Cholinergic deafferentation of the rabbit cortex: a new animal model of A beta deposition", NEUROSCI L, 283(1), 2000, pp. 9-12

Abstract

Brain deposition of the amyloid p-peptide (AP) is a critical step in the pathogenesis of Alzheimer's disease (AD) and human cerebral amyloid angiopathy (CAA). A small fraction of AD and CAA cases are caused by gene mutationsleading to increased production and deposition of AP, but for the majority, there is no known direct genetic cause. We have hypothesized that AP deposition in these sporadic cases occurs as a result of cortical cholinergic deafferentation. Here we show that cortical cholinergic deafferentation, induced in rabbits by a selective immunotoxin, leads to Ap deposition in cerebral blood vessels and perivascular neuropil. Biochemical measurements confirmed that lesioned animals had 2.5- and 8-fold elevations of cortical A beta 40 and A beta 42, respectively. Cholinergic deafferentation may be one factor that can contribute to AP deposition. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:01:26