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Titolo:
Differential effects of melanocortin peptides on ingestive behaviour in rats: evidence against the involvement of MC3 receptor in the regulation of food intake
Autore:
Kask, A; Rago, L; Wikberg, JES; Schioth, HB;
Indirizzi:
Univ Tartu, Fac Med, Dept Pharmacol, EE-50411 Tartu, Estonia Univ Tartu Tartu Estonia EE-50411 ept Pharmacol, EE-50411 Tartu, Estonia Uppsala Univ, Dept Pharmaceut Pharmacol, Uppsala, Sweden Uppsala Univ Uppsala Sweden Dept Pharmaceut Pharmacol, Uppsala, Sweden Melacure Therapeut, Uppsala, Sweden Melacure Therapeut Uppsala SwedenMelacure Therapeut, Uppsala, Sweden
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 283, anno: 2000,
pagine: 1 - 4
SICI:
0304-3940(20000331)283:1<1:DEOMPO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIOLIGAND BINDING; BETA-ENDORPHIN; MICE; ACTH-(1-24); OBESITY; PROTEIN;
Keywords:
proopiomelanocortin; alpha-melanocyte-stimulating hormone; beta-melanocyte-stimulating hormone; gamma-melanocyte-stimulating hormone; food intake; feeding; melanocortin receptors; satiety; water intake;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Kask, A Univ Tartu, Fac Med, Dept Pharmacol, Ravila 19, EE-50411 Tartu, Estonia Univ Tartu Ravila 19 Tartu Estonia EE-50411 -50411 Tartu, Estonia
Citazione:
A. Kask et al., "Differential effects of melanocortin peptides on ingestive behaviour in rats: evidence against the involvement of MC3 receptor in the regulation of food intake", NEUROSCI L, 283(1), 2000, pp. 1-4

Abstract

The pro-opiomelanocortin-derived peptides decrease food intake possibly via MC4 receptor. In this study we compared the effects of alpha-melanocyte-stimulating hormone (MSH), beta-MSH and gamma(1)-MSH (0.2, 1.0 and 5.0 mu g, i.c.v.) on food intake. alpha-MSH and beta-MSH inhibited spontaneous foodintake in a dose dependent manner, whereas the gamma(1)-MSH did not. alpha-MSH and beta-MSH but not gamma(1)-MSH tall 5.0 mu g, i.c.v. inhibited fasting-induced food intake about 50%. None of the three peptides inhibited fluid consumption in water-deprived (24 h) rats. It is suggested that MC, receptor, activated selectively by gamma(1)-MSH, is not involved in the regulation of food intake. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 19:21:15