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Titolo:
Immunohistochemical localization of gamma-aminobutyric acid(B) receptor inthe hippocampus of subjects with schizophrenia
Autore:
Mizukami, K; Sasaki, M; Ishikawa, M; Iwakiri, M; Hidaka, S; Shiraishi, H; Iritani, S;
Indirizzi:
Univ Tsukuba, Inst Clin Med, Dept Psychiat, Tsukuba, Ibaraki 305, Japan Univ Tsukuba Tsukuba Ibaraki Japan 305 chiat, Tsukuba, Ibaraki 305, Japan Tokyo Metropolitan Matsuzawa Hosp, Dept Psychiat, Tokyo 156, Japan Tokyo Metropolitan Matsuzawa Hosp Tokyo Japan 156 hiat, Tokyo 156, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 283, anno: 2000,
pagine: 101 - 104
SICI:
0304-3940(20000407)283:2<101:ILOGAR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREFRONTAL CORTEX; NEURONS; EXPRESSION; BINDING; GENE; CLONING; GABAA;
Keywords:
gamma-aminobutyric acid(B) receptor; schizophrenia; immunohistochemistry; hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Mizukami, K Univ Tsukuba, Inst Clin Med, Dept Psychiat, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305, Japan Univ Tsukuba 1-1-1 Tennoudai Tsukuba Ibaraki Japan 305 , Japan
Citazione:
K. Mizukami et al., "Immunohistochemical localization of gamma-aminobutyric acid(B) receptor inthe hippocampus of subjects with schizophrenia", NEUROSCI L, 283(2), 2000, pp. 101-104

Abstract

Recent studies have demonstrated the involvements of gamma-aminobutyric acid (GABA) neurotransmitter systems in the schizophrenic brain. In order to further elucidate the alterations of this system in schizophrenia, we employed immunohistochemical techniques and examined the expression and anatomical distribution of the GABA(B) receptor in the hippocampus of five subjectswith schizophrenia and three age-matched controls. In the control hippocampus, the most intense immunoreactivity was observed in the soma and processes of multipolar interneurons throughout the hippocampus. Pyramidal cells too were intensely labeled in their soma and proximal portion of dendrites, although the labeling intensity was varied in each subregion. For example, in the CA1 subfield, the labeling intensity of pyramidal cells was much less intense than that in the CA3 and CA2 subfields. In the subjects with schizophrenia, GABA(B) immunoreactivity was markedly reduced in granule cells as well as in pyramidal cells throughout the CA fields. In interneurons, GABA(B) labeling was relatively preserved compared to that in pyramidal cells. Our findings suggest that in the hippocampus of schizophrenic patients theexpression of the GABAB receptor is reduced, and raise the possibility that this reduction contributes to the pathophysiological process in the schizophrenic brain. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:39:57