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Titolo:
Enantio-selective occurrence of (S)-tetrahydropapaveroline in human brain
Autore:
Sango, K; Maruyama, W; Matsubara, K; Dostert, P; Minami, C; Kawai, M; Naoi, M;
Indirizzi:
Nagoya Inst Technol, Dept Appl Chem, Nagoya, Aichi 466, Japan Nagoya Inst Technol Nagoya Aichi Japan 466 Chem, Nagoya, Aichi 466, Japan Nagoya Inst Technol, Dept Biosci, Nagoya, Aichi 466, Japan Nagoya Inst Technol Nagoya Aichi Japan 466 osci, Nagoya, Aichi 466, Japan Natl Inst Longev Sci, Dept Basic Gerontol, Lab Biochem & Metab, Aichi, Japan Natl Inst Longev Sci Aichi Japan tol, Lab Biochem & Metab, Aichi, Japan Asahikawa Med Coll, Dept Pharm, Asahikawa, Hokkaido 078, Japan Asahikawa Med Coll Asahikawa Hokkaido Japan 078 kawa, Hokkaido 078, Japan Biotrial, Rennes, France Biotrial Rennes FranceBiotrial, Rennes, France
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 283, anno: 2000,
pagine: 224 - 226
SICI:
0304-3940(20000414)283:3<224:EOO(IH>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
TETRAHYDROISOQUINOLINE ALKALOIDS; DOPAMINERGIC NEUROTOXIN; BIOSYNTHETIC-PATHWAY; L-DOPA; MORPHINE; N-METHYL(R)SALSOLINOL; CODEINE; ENZYME; LIVER;
Keywords:
tetrahydropapaveroline; human brain; morphine; enantio-specificity; dopamine; monoamine oxidase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Naoi, M Inst Appl Biochem, Dept Brain Sci, Yagi Mem Pk, Gifu 5050116, Japan Inst Appl Biochem Yagi Mem Pk Gifu Japan 5050116 u 5050116, Japan
Citazione:
K. Sango et al., "Enantio-selective occurrence of (S)-tetrahydropapaveroline in human brain", NEUROSCI L, 283(3), 2000, pp. 224-226

Abstract

Tetrahydropapaveroline is an endogenous complex alkaloid derived from dopamine through the oxidation by monoamine oxidase. This alkaloid is considered to be involved in the pathogenesis of alcoholism and to act as a false neurotransmitter. Recently the (S) enantiomer was proposed to be a precursor of morphine biosynthesis in the opium poppy. In this paper stereo-chemical characteristic of tetrahydropapaveroline in human brains was examined. In all four control human brains examined, only the (S)-tetrahydropapaveroline was detected. The concentrations were 0.12-0.22 pmol/g wet weight of brain tissue, and the presence of alcohol in blood did not affect the concentration. The results suggest that (S)-tetrahydropapaveroline may be enantio-selectively synthesized in human brain and it may be an intermediate of the de novo synthesis of morphine analogues. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 23:44:10