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Titolo:
The role of 5-HT1A and 5-HT1B/1D receptors on the modulation of acute fluoxetine-induced changes in extracellular 5-HT: the mechanism of action of (+/-)pindolol
Autore:
Dawson, LA; Nguyen, HQ;
Indirizzi:
Wyeth Ayerst Res, CNS Disorders Div, Princeton, NJ 08543 USA Wyeth Ayerst Res Princeton NJ USA 08543 ders Div, Princeton, NJ 08543 USA
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 6, volume: 39, anno: 2000,
pagine: 1044 - 1052
SICI:
0028-3908(2000)39:6<1044:TRO5A5>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACEBO-CONTROLLED TRIAL; SEROTONIN REUPTAKE INHIBITORS; IN-VIVO MICRODIALYSIS; FREELY MOVING RATS; MAJOR DEPRESSION; FRONTAL-CORTEX; DOUBLE-BLIND; PHARMACOLOGICAL CHARACTERIZATION; AUTORECEPTOR BLOCKADE; ANTIDEPRESSANT DRUGS;
Keywords:
5-HT; microdialysis; 5-HT1A; 5-HT1B; (+/-)pindolol; fluoxetine; antagonist;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Dawson, LA Wyeth Ayerst Res, CNS Disorders Div, CN8000, Princeton, NJ 08543 USA Wyeth Ayerst Res CN8000 Princeton NJ USA 08543 on, NJ 08543 USA
Citazione:
L.A. Dawson e H.Q. Nguyen, "The role of 5-HT1A and 5-HT1B/1D receptors on the modulation of acute fluoxetine-induced changes in extracellular 5-HT: the mechanism of action of (+/-)pindolol", NEUROPHARM, 39(6), 2000, pp. 1044-1052

Abstract

Some clinical evidence has suggested that (+/-)pindolol can be effective at producing a shortened time to onset of antidepressant activity when co-administered with a Serotonin specific reuptake inhibitor (SSRI). This effecthas been attributed to the antagonist effects of pindolol at the 5-HT1A receptor. In the present study, we compared the pharmacology of (+/-)pindolol, WAY-100635 (a 5-HT1A antagonist), GR127935 (a 5-HT1B/1D antagonist), and isamoltane (a 5-HT1B antagonist), when given acutely in combination with fluoxetine. using in vivo microdialysis in the frontal cortex of the freely moving rat. We have determined that the acute fluoxetine-induced increases in extracellular 5-HT can be augmented by (+/-)pindolol. WAY100635, GR127935and isamoltane with maximum increases of 216+/-32%. 235+/-49%, 240+/-18% and 171+/-47% of preinjection control levels, respectively. Combination of both 5-HT1A and 5-HT1B/1D autoreceptor antagonists with fluoxetine produced additive increases in extracellular 5-HT (i.e. WAY100635+GR127935+fluoxetine and WAY100635+isamoltane+fluoxetine produced a four- and five-fold potentiation, respectively), suggesting that this strategy may be useful in further augmenting the action of a SSRI in the. treatment of depression In addition, by comparing the combined administration of(+/-)pindolol with tither WAY100635, GR127935 or isamoltane, we have determined that (+/-)pindolol produces much of its acute potentiation of fluoxetine-induced increases in extracellular 5-HT via its action at the 5-HT1B/D receptor in addition to any activity it has at the presynaptic 5-HT1A receptor. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 22:32:13