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Titolo:
Opioid propeptide mRNA content and receptor density in the brains of AA and ANA rats
Autore:
Marinelli, PW; Kiianmaa, K; Gianoulakis, C;
Indirizzi:
Douglas Hosp, Res Ctr, Dept Psychiat, Montreal, PQ, Canada Douglas Hosp Montreal PQ Canada Ctr, Dept Psychiat, Montreal, PQ, Canada McGill Univ, Montreal, PQ, Canada McGill Univ Montreal PQ CanadaMcGill Univ, Montreal, PQ, Canada Natl Publ Hlth Inst, Alcohol Res Ctr, Helsinki, Finland Natl Publ Hlth Inst Helsinki Finland Alcohol Res Ctr, Helsinki, Finland
Titolo Testata:
LIFE SCIENCES
fascicolo: 20, volume: 66, anno: 2000,
pagine: 1915 - 1927
SICI:
0024-3205(20000407)66:20<1915:OPMCAR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALCOHOL-PREFERRING AA; BETA-ENDORPHIN SYSTEM; FREELY MOVING RATS; DOPAMINE RELEASE; DBA/2 MICE; ETHANOL-CONSUMPTION; ENDOGENOUS OPIOIDS; NUCLEUS-ACCUMBENS; BINDING-SITES; MU;
Keywords:
ethanol; kappa; mu; proopiomelanocortin; proenkephalin; prodynorphin; reinforcement;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Gianoulakis, C Douglas Hosp, Res Ctr, 6875 Boul LaSalle, Verdun, PQ H4H 1R3, Canada Douglas Hosp 6875 Boul LaSalle Verdun PQ Canada H4H 1R3 ada
Citazione:
P.W. Marinelli et al., "Opioid propeptide mRNA content and receptor density in the brains of AA and ANA rats", LIFE SCI, 66(20), 2000, pp. 1915-1927

Abstract

Recent evidence has indicated an association between the rewarding effectsof ethanol intake and endogenous opioid activity. The present studies examine the presence of differences in opioid peptide mRNA content and mu and kappa opioid receptor densities, between ethanol naive AA and ANA rats bred selectively for their high and low alcohol consumption, respectively. In situ hybridization was used to compare the content of proopiomelanocortin, proenkephalin and prodynorphin mRNA in distinct brain regions known to be involved in the reinforcing properties of addictive drugs, between rats from each line. Results indicated that AA rats had a significantly greater content of proopiomelanocortin mRNA in the arcuate nucleus of the hypothalamus, of proenkephalin mRNA in the prefrontal cortex and of prodynorphin mRNA in the mediodorsal nucleus of the thalamus (p less than or equal to .05). Receptor autoradiography was performed using H-3-labeled ligands specific for muand kappa opioid receptors. AA rats were found to have a greater density of mu opioid receptors in the shell region of the nucleus accumbens and prefrontal cortex, but a lower density of kappa opioid receptors in the ventromedial hypothalamus, compared to ANA rats. The present data demonstrate the presence of inherited differences in the activity of distinct components ofthe endogenous opioid system in some brain regions associated with the processes of reward and reinforcement; and as such, may play a role in determining differences in ethanol drinking between AA and ANA rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:26:38