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Titolo:
Assessment of coronary flow reserve with transthoracic Doppler echocardiography: Comparison among adenosine, standard-dose dipyridamole, and high-dose dipyridamole
Autore:
Lim, HE; Shim, WJ; Rhee, H; Kim, SM; Hwang, GS; Kim, YH; Seo, HS; Oh, DJ; Ro, YM;
Indirizzi:
Korea Univ, Coll Med, Dept Internal Med, Div Cardiol, Seoul 136701, South Korea Korea Univ Seoul South Korea 136701 v Cardiol, Seoul 136701, South Korea
Titolo Testata:
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
fascicolo: 4, volume: 13, anno: 2000,
pagine: 264 - 270
SICI:
0894-7317(200004)13:4<264:AOCFRW>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR HYPERTROPHY; MYOCARDIAL BLOOD-FLOW; ARTERY DISEASE; NONINVASIVE ASSESSMENT; VASODILATOR RESERVE; GUIDE-WIRE; INTRAVENOUS DIPYRIDAMOLE; VELOCITY RESERVE; ANGINA-PECTORIS; STENOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Shim, WJ Korea Univ, Coll Med, Dept Internal Med, Div Cardiol, 126-1,5-Ga Anam-Dong,Sung Buk-Ku, Seoul 136701, South Korea Korea Univ 126-1,5-Ga Anam-Dong,Sung Buk-Ku Seoul South Korea 136701
Citazione:
H.E. Lim et al., "Assessment of coronary flow reserve with transthoracic Doppler echocardiography: Comparison among adenosine, standard-dose dipyridamole, and high-dose dipyridamole", J AM S ECHO, 13(4), 2000, pp. 264-270

Abstract

Coronary flow reserve (CFR), defined as a ratio of hyperemic-to-basal coronary now velocity, provides important information about the functional aspect of coronary circulation. However, it usually is determined by invasive methods during catheterization. Recent studies have shown that transthoracicDoppler echocardiography (TTDE) may be useful in the measurement of coronary now velocity in the distal portion of the left anterior descending coronary artery (LAD). The vasodilators used for hyperemia are adenosine and dipyridamole. However, the coronary vasodilative response and systemic hemodynamic effects of the two agents have not been directly compared with TTDE. We assessed blood flow velocity and vascular resistance in the distal LAD byTTDE during an intravenous a-minute adenosine infusion (140 mu g/kg/min) and low- (0.56 mg/kg) and high-dose dipyridamole (0.84 mg/kg) infusion in 25patients with patent LAD. Coronary now velocity was successfully recorded in 20 patients (80%) during baseline and the consecutive vasodilator-infusion period. Compared with low-dose dipyridamole, adenosine infusion induced a higher CFR (3.7 +/- 0.87 vs 2.73 +/- 0.65; P < .05) and a lower coronary resistance index (0.31 +/- 0.04 vs 0.35 a 0.08; P < .05). But by increasingthe dipyridamole dose to 0.84 mg/kg, the values of the CFR and coronary resistance index became comparable to those of adenosine infusion (2.85 +/- 0.78 vs 3.03 +/- 0.7, P = not significant [NS]; 0.33 +/- 0.04 vs 0.32 +/- 0.09, P = NS; respectively). We conclude that adenosine seems to be a favorable vasodilator for the measurement of CFR with TTDE.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 08:55:22