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Titolo:
Vagus-mediated activation of mucosal mast cells in the stomach: Effect of ketotifen on gastric mucosal lesion formation and acid secretion induced bya high dose of intracisternal TRH analogue
Autore:
Kiraly, A; Suto, G; Tam, B; Hermann, V; Mozsik, G;
Indirizzi:
Univ Pecs, Sch Med, Dept Med 1, H-7643 Pecs, Hungary Univ Pecs Pecs Hungary H-7643 Sch Med, Dept Med 1, H-7643 Pecs, Hungary
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 2, volume: 94, anno: 2000,
pagine: 131 - 134
SICI:
0928-4257(200003/04)94:2<131:VAOMMC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROTROPIN-RELEASING-HORMONE; NERVOUS-SYSTEM ACTION; RATS; STIMULATION; HISTAMINE; INJECTION; EROSIONS; RX-77368; ETHANOL; NUCLEI;
Keywords:
TRH analogue; vagus; mast cells; gastric mucosal lesion; gastric acid secretion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Mozsik, G Univ Pecs, Sch Med, Dept Med 1, Ifjusag Str 13, H-7643 Pecs, Hungary Univ Pecs Ifjusag Str 13 Pecs Hungary H-7643 7643 Pecs, Hungary
Citazione:
A. Kiraly et al., "Vagus-mediated activation of mucosal mast cells in the stomach: Effect of ketotifen on gastric mucosal lesion formation and acid secretion induced bya high dose of intracisternal TRH analogue", J PHYSL-PAR, 94(2), 2000, pp. 131-134

Abstract

TRH analogue, RX 77368, injected intracisternally (i.c.) at high dose (3 mu g/rat) produces gastric mucosal lesion formation through vagal-dependent pathway. The gastric mucosal hyperemia induced by i.c. RX 77368 was shown to be mediated by muscarinic vagal efferent fibres and mast cells. Furthermore, electrical vagal stimulation was observed to induce gastric mucosal mast cell degranulation. The aim of the study was to assess the influence of ketotifen, a mast cell stabilizer, on RX 77368-induced gastric lesion formation and gastric acid secretion. RX 77368 (3 mu g, i.c.) or vehicle (10 mu L, i.c.) was delivered 240 min prior to the sacrifice of the animals. Ketotifen or vehicle (0.9% NaCl, 0.5 mt) was injected intraperitoneally (i.p.) ata dose of 10 mg.kg(-1) 30 min before RX 77368 injection. The extent of mucosal damage was planimetrically measured by a video image analyzer (ASK Ltd., Budapest) device. In the gastric acid secretion studies, the rats were pretreated with ketotifen (10 mg.kg(-1), i.p.) or vehicle (0.9% NaCl, 0.5 mt, i.p.), 30 min later pylorus-ligation was performed and RX 77368 (3 mu g, i.c.) or vehicle (0.9% NaCl, 10 mu L, i.c.) was injected. The rats were killed 240 min after i.c. injection, and the gastric acid secretion was measured through the titration of gastric contents with 0.1 N NaOH to pH 7.0. RX 77368 (3 mu g, i.c.) resulted in a gastric mucosal lesion formation involving 8.2% of the corpus mucosa (n = 7). Ketotifen elicited an 85% inhibition on the development of mucosal lesions (n = 7, P < 0.001) whereas ketotifen alone had no effect on the lesion formation in the mucosa (n = 7). The RX 77368 induced increase of gastric acid secretion was not influenced by ketotifen pretreatment in 4-h pylorus-ligated animals. Central vagal activation induced mucosal lesion formation is mediated by the activation of mucosal mast cells in the stomach. Mast cell inhibition by ketotifen does not influence gastric acid secretion induced by i.c. TRH analogue in 4-h pylorus-ligated rats. (C) 2000 Elsevier Science Ltd. Published by Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:43:04