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Titolo:
The antidepressant effect of an antiulcer pentadecapeptide BPC 157 in Porsolt's test and chronic unpredictable stress in rats. A comparison with antidepressants
Autore:
Sikiric, P; Separovic, J; Buljat, G; Anic, T; Stancic-Rokotov, D; Mikus, D; Marovic, A; Prkacin, I; Duplancic, B; Zoricic, I; Aralica, G; Lovric-Bencic, M; Ziger, T; Perovic, D; Rotkvic, I; Mise, S; Hanzevacki, M; Hahn, V; Seiwerth, S; Turkovic, B; Grabarevic, Z; Petek, M; Rucman, R;
Indirizzi:
Univ Zagreb, Fac Med, Dept Pharmacol, Zagreb 41000, Croatia Univ Zagreb Zagreb Croatia 41000 , Dept Pharmacol, Zagreb 41000, Croatia
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 2, volume: 94, anno: 2000,
pagine: 99 - 104
SICI:
0928-4257(200003/04)94:2<99:TAEOAA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESTRAINT STRESS; ANIMAL-MODELS; BPC-157; LESIONS; DEPRESSION; PEPTIDE; DOPAMINE; CYSTEAMINE; ETHANOL;
Keywords:
stomach antiulcer pentadecapeptide BPC 157; Porsolt's procedure; chronic stress; antidepressants;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Sikiric, P Univ Zagreb, Fac Med, Dept Pharmacol, Zagreb 41000, Croatia Univ Zagreb Zagreb Croatia 41000 macol, Zagreb 41000, Croatia
Citazione:
P. Sikiric et al., "The antidepressant effect of an antiulcer pentadecapeptide BPC 157 in Porsolt's test and chronic unpredictable stress in rats. A comparison with antidepressants", J PHYSL-PAR, 94(2), 2000, pp. 99-104

Abstract

Various antidepressants have antiulcer activity. Likewise, the models currently used in ulcers and depression disorders research have a considerable degree of similarity. Therefore, the possibility that depression disorders could be effectively influenced by a primary antiulcer agent with a cyto/organoprotective activity, such as the novel stomach pentadecapeptide BPC 157, was investigated in two rat depression assays. First, a forced swimming test (a Porsolt's procedure) was used. As a more severe procedure, chronic unpredictable stress (after 5 d of unpredictable stress protocol, once dailydrug application during stress procedure, open field-immobility test assessment at fourth or sixth day of medication) was used. In a forced swimming test, a reduction of the immobility time in BPC 157 (10 mu g, 10 ng.kg(-1) i.p.) treated rats corresponds to the activity of the 15 mg or 40 mg (i.p.)of conventional antidepressants, imipramine or nialamide, respectively, given according to the original Porsolt's protocol. In chronic unpredictable stress procedure, particular aggravation of experimental conditions markedly affected the conventional antidepressant activity, whereas BPC 157 effectiveness was continuously present. The effect of daily imipramine (30 mg) medication could be seen only after a more prolonged period, but not after a shorter period (i.e., 4-d protocol). In these conditions, no delay in the effectiveness was noted in BPC 157 medication and a reduction of the immobility of chronically stressed rats was noted after both 4 and 6 d of BPC 157 (10 mu g, 10 ng) medication. (C) 2000 Elsevier Science Ltd. Published by Editions scientifiques et medicales Elsevier SAS.

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Documento generato il 15/07/20 alle ore 07:17:51