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Titolo:
Ibotenic acid-induced lesions of the medial septum increase hippocampal membrane associated protein kinase C activity and reduce acetylcholine synthesis: Prevention by a phosphatidylcholine/vitamin B-12 diet
Autore:
Hung, MC; Shibasaki, K; Nishizono, S; Sato, M; Ikeda, I; Masuda, Y; Kunou, M; Kawamura, M; Yamashita, M; Inoue, S; Imaizumi, K;
Indirizzi:
Kyushu Univ, Grad Sch, Div Bioresource & Bioenvironm, Nutr Chem Lab, Fukuoka 8128581, Japan Kyushu Univ Fukuoka Japan 8128581 Nutr Chem Lab, Fukuoka 8128581, Japan QP Corp, Inst Res, Tokyo, Japan QP Corp Tokyo JapanQP Corp, Inst Res, Tokyo, Japan Kochi Prefectural Geiyo Hosp, Kochi, Japan Kochi Prefectural Geiyo Hosp Kochi Japan tural Geiyo Hosp, Kochi, Japan Kochi Med Sch, Dept Neuropsychiat, Kochi 783, Japan Kochi Med Sch Kochi Japan 783 Sch, Dept Neuropsychiat, Kochi 783, Japan
Titolo Testata:
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
fascicolo: 3, volume: 11, anno: 2000,
pagine: 159 - 164
SICI:
0955-2863(200003)11:3<159:IALOTM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA-MEMBRANES; BRAIN MEMBRANES; BINDING; CHOLINE; NEURONS; RATS; DEFICIENCY; RECEPTORS; MEMORY; MICE;
Keywords:
acetylcholine; choline acetyltransferase; ibotenic acid; phosphatidylcholine; protein kinase C; vitamin B-12;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Imaizumi, K Kyushu Univ, Grad Sch, Div Bioresource & Bioenvironm, Nutr Chem Lab, Fukuoka 8128581, Japan Kyushu Univ Fukuoka Japan 8128581 ab, Fukuoka 8128581, Japan
Citazione:
M.C. Hung et al., "Ibotenic acid-induced lesions of the medial septum increase hippocampal membrane associated protein kinase C activity and reduce acetylcholine synthesis: Prevention by a phosphatidylcholine/vitamin B-12 diet", J NUTR BIOC, 11(3), 2000, pp. 159-164

Abstract

Ibotenic acid infusion into the medial septum (MS) results in biochemical alterations in the hippocampus. The biochemical events involved in this neuronal lesion are poorly understood. We investigated the effect of a purified diet supplemented with egg phosphatidylcholine (PC) and vitamin B-12 on ibotenic acid-medicated biochemical changes in the rat hippocampus and crudesynaptosomal membranes. Male Wistar mts with this MS lesion were fed a purified diet (control diet) or a purified diet supplemented with 5.7 g PC and125 mu g vitamin B-12 per 100 g (experimental diet)for 18 days. Sham-operated mts were fed the control diet. Compared,vith the sham-operated mts, MS-lesioned rats fed the control diet showed increased activity of membrane-bound protein kinase C (PKC), decreased activity of choline acetyltransferase, and decreased concentrations of acetylcholine in the hippocampus. The ratio of cholesterol to phospholipid in the crude synaptic membrane was lower in the lesioned mts than in the sham-operated mts, but this was not accompanied by any alteration in membrane lipid fluidity. MS-lesioned rats fed theexperimental diet showed lowered PKC activity and elevated acetylcholine concentrations than did rats fed the control diet, but there were no significant effects on choline acetyltransfease activity and the lipid ratio. The ibotenic acid-mediated elevation of PKC activity was observed as early as 2days postinjury in the control diet-fed rats but not in the experimental diet-fed rats. We propose that ibotenic acid mediates pathophysiologic actions through the activation of PKC and that PC combined with vitamin B-12 ameliorates the second messenger-mediated injury. (C) Elsevier Science Inc. 2000. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 14:06:15