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Titolo:
Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis
Autore:
Clee, SM; Bissada, N; Miao, FD; Miao, L; Marais, AD; Henderson, HE; Steures, P; McManus, J; McManus, B; LeBoeuf, RC; Kastelein, JJP; Hayden, MR;
Indirizzi:
Univ British Columbia, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada Univ British Columbia Vancouver BC Canada V5Z 4H4 ver, BC V5Z 4H4, Canada Univ Cape Town, Dept Internal Med, ZA-7925 Cape Town, South Africa Univ Cape Town Cape Town South Africa ZA-7925 25 Cape Town, South Africa Red Cross Childrens Hosp, Dept Clin Pathol, ZA-7700 Cape Town, South Africa Red Cross Childrens Hosp Cape Town South Africa ZA-7700 wn, South Africa Univ British Columbia, St Pauls Hosp, Dept Pathol & Lab Med, Vancouver, BCV6Z 1Y6, Canada Univ British Columbia Vancouver BC Canada V6Z 1Y6 uver, BCV6Z 1Y6, Canada Univ Washington, Dept Pathobiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Pathobiol, Seattle, WA 98195 USA Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands
Titolo Testata:
JOURNAL OF LIPID RESEARCH
fascicolo: 4, volume: 41, anno: 2000,
pagine: 521 - 531
SICI:
0022-2275(200004)41:4<521:PAVWLL>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; MYOCARDIAL-INFARCTION SURVIVORS; CORONARY-ARTERY DISEASE; TRIGLYCERIDE-RICH LIPOPROTEINS; DIET-INDUCED ATHEROSCLEROSIS; ISCHEMIC-HEART-DISEASE; SMOOTH-MUSCLE CELLS; EXTRACELLULAR-MATRIX; HEPARAN-SULFATE; GENE POLYMORPHISMS;
Keywords:
apoE-deficient mice; triglycerides; HDL; lipoprotein retention; C57BL/6;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Hayden, MR Univ British Columbia, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada Univ British Columbia Vancouver BC Canada V5Z 4H4 4H4, Canada
Citazione:
S.M. Clee et al., "Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis", J LIPID RES, 41(4), 2000, pp. 521-531

Abstract

Lipoprotein lipase (LPL) is a key enzyme in lipoprotein metabolism, and has been hypothesized to exert either pro- or anti-atherogenic effects, depending on its localization. Decreased plasma LPL activity is associated with the high triglyceride (TG)-low HDL phenotype that is often observed in patients with premature vascular disease. In contrast, in the vessel wall, decreased LPL may be associated with less lipoprotein retention due to many potential mechanisms and, therefore, decreased foam cell formation. To directly assess this hypothesis, we have distinguished between the effects of variations in plasma and/or vessel wall LPL on atherosclerosis susceptibility in apoE-deficient mice. Reduced LPL in both plasma and vessel wall (LPL+/- E-/-) was associated with increased TG and increased total cholesterol (TC) compared with LPL+/+E-/- sibs, However despite their dyslipidemia, LPL+/-E-/- mice had significantly reduced lesion areas compared to the LPL(+/+)E(-/-)mice. Thus, decreased vessel wall LPL was associated with decreased lesion formation even in the presence of reduced plasma LPL activity. In contrast, transgenic mice with increased plasma LPL but with no increase in LPL expression in macrophages, and thus the vessel wall, had decreased TG and TC and significantly decreased lesion areas compared with LPL+/+E-/- mice. This demonstrates that increased plasma LPL activity alone, in the absence of an increase in vessel wall LPL, is associated with reduced susceptibility to atherosclerosis. Taken together these results provide in vivo evidence that the contribution of LPL to atherogenesis is significantly influenced by the balance between vessel wall protein (pro-atherogenic) and plasma activity (anti-atherogenic).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:34:16