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Titolo:
MOUSE ADHALIN - PRIMARY STRUCTURE AND EXPRESSION DURING LATE STAGES OF MUSCLE DIFFERENTIATION IN-VITRO
Autore:
LIU L; VACHON PH; KUANG W; XU H; WEWER UM; KYLSTEN P; ENGVALL E;
Indirizzi:
LA JOLLA CANC RES FDN,CANC RES CTR,BURNHAM INST,10901 N TORREY PINES RD LA JOLLA CA 92037 LA JOLLA CANC RES FDN,CANC RES CTR,BURNHAM INST LA JOLLA CA 92037 UNIV STOCKHOLM,WENNER GREN INST,DEPT DEV BIOL S-10691 STOCKHOLM SWEDEN UNIV COPENHAGEN,INST MOL PATHOL DK-2100 COPENHAGEN DENMARK
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 1, volume: 235, anno: 1997,
pagine: 227 - 235
SICI:
0006-291X(1997)235:1<227:MA-PSA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GIRDLE MUSCULAR-DYSTROPHY; GLYCOPROTEIN COMPLEX; SARCOGLYCAN COMPLEX; BASEMENT-MEMBRANE; BETA-SARCOGLYCAN; SKELETAL-MUSCLE; GENE; LAMININ; LINKAGE; DEFICIENCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
L. Liu et al., "MOUSE ADHALIN - PRIMARY STRUCTURE AND EXPRESSION DURING LATE STAGES OF MUSCLE DIFFERENTIATION IN-VITRO", Biochemical and biophysical research communications, 235(1), 1997, pp. 227-235

Abstract

Adhalin, or alpha-sarcoglycan, is a 50-kDa glycoprotein that was originally characterized as a muscle membrane protein. The importance of adhalin is suggested by the diseases associated with its absence, notably the limb-gridle muscular dystrophies. However, the function of adhalin is unknown. To analyze the biological roles of adhalin, we cloned the mouse adhalin cDNA, raised peptide-specific antibodies to its cytoplasmic domain, and examined its expression and localization in vivo and in vitro. The mouse adhalin sequence was 80% identical to that of human, rabbit, and hamster. Adhalin was specifically expressed in striated muscle cells and their immediate precursors, and absent in many other cell types. Adhalin expression in embryonic mouse muscle was coincident with primary myogenesis. Its expression was found to be up-regulated at mRNA and protein levels during myogenic differentiation in vitro. The proper localization of adhalin to the muscle cell membrane wasobserved only in late stages of myotube maturation, coincident with the re-distribution of caveolin-3 and dystrophin. These data suggest that adhalin is highly specific for striated muscle and that it is linked with the formation of a fully functional muscle fiber. (C) 1997 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 09:47:25