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Titolo:
Nutritional osteomalacia - Substantial clinical improvement and gain in bone density posttherapy
Autore:
Al-Ali, H; Fuleihan, GE;
Indirizzi:
Amer Univ Beirut, Med Ctr, Calcium Metab & Osteoporosis Program, Dept Med,Beirut, Lebanon Amer Univ Beirut Beirut Lebanon rosis Program, Dept Med,Beirut, Lebanon
Titolo Testata:
JOURNAL OF CLINICAL DENSITOMETRY
fascicolo: 1, volume: 3, anno: 2000,
pagine: 97 - 101
SICI:
1094-6950(200021)3:1<97:NO-SCI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY HYPERPARATHYROIDISM; PARATHYROID-HORMONE; MINERAL DENSITY; DISEASE;
Keywords:
vitamin D deficiency; nutritional osteomalacia; bone mineral density; bone pain; weakness;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Fuleihan, GE Amer Univ Beirut, Med Ctr, Calcium Metab & Osteoporosis Program, Dept Med,Bliss St, Beirut, Lebanon Amer Univ Beirut Bliss St Beirut Lebanon t, Beirut, Lebanon
Citazione:
H. Al-Ali e G.E. Fuleihan, "Nutritional osteomalacia - Substantial clinical improvement and gain in bone density posttherapy", J CLIN DENS, 3(1), 2000, pp. 97-101

Abstract

A 52-yr-old white female presented with worsening low back and hip pain, associated with lower limb proximal muscle weakness and a waddling gait. Herlaboratory evaluation revealed hypocalcemia, hypophosphatemia, a very low 25-hydroxyvitamin D level of less than 5 ng/ml, and a bone mineral density in the osteoporotic range. Her laboratory studies were consistent with osteomalacia, although this diagnosis was not established by histomorphometry. She avoided dairy products, spent little time outdoors, and when she went out, she covered her face, arms, and legs. She was on no medications. Her workup for malabsorption including sprue was negative. She was treated with calcium plus high-dose vitamin D 600,000 IU intramuscularly twice within 2 mo and had an impressive clinical improvement. Her difficulty with ambulation improved within 1 wk of start of therapy. Her bone mineral density increased by 40% at the spine and 35% at the hip at 4 mo of therapy, by 63% and 39% at 10 mo, and by 62% and 52% at 15 mo at these sites, respectively. Treatment of osteomalacia is extremely rewarding, with dramatic clinical improvement and normalization of bone mineral density.

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Documento generato il 14/07/20 alle ore 07:02:43