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Titolo:
Subtle brain damage cannot be detected by measuring neuron-specific enolase and S-100 beta protein after carotid endarterectomy
Autore:
Rasmussen, LS; Christiansen, M; Johnsen, J; Gronholdt, ML; Moller, JT;
Indirizzi:
Copenhagen Univ Hosp, Dept Anesthesia, Ctr Head & Orthoped, Rigshosp, DK-2100 Copenhagen, Denmark Copenhagen Univ Hosp Copenhagen Denmark DK-2100 2100 Copenhagen, Denmark Copenhagen Univ Hosp, Rigshosp, Dept Vasc Surg, Abdominal Ctr, DK-2100 Copenhagen, Denmark Copenhagen Univ Hosp Copenhagen Denmark DK-2100 2100 Copenhagen, Denmark State Serum Inst, Dept Clin Biochem, Copenhagen, Denmark State Serum InstCopenhagen Denmark t Clin Biochem, Copenhagen, Denmark
Titolo Testata:
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
fascicolo: 2, volume: 14, anno: 2000,
pagine: 166 - 170
SICI:
1053-0770(200004)14:2<166:SBDCBD>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID; SURGERY; BLOOD; DISEASE; STROKE; PLASMA; EMBOLI; SERUM;
Keywords:
carotid endarterectomy; cognitive dysfunction; neuropsychologic tests; neuron-specific enolase; S-100 beta protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Rasmussen, LS Copenhagen Univ Hosp, Dept Anesthesia, Ctr Head & Orthoped, Rigshosp, 4132, DK-2100 Copenhagen, Denmark Copenhagen Univ Hosp 4132 Copenhagen Denmark DK-2100 enmark
Citazione:
L.S. Rasmussen et al., "Subtle brain damage cannot be detected by measuring neuron-specific enolase and S-100 beta protein after carotid endarterectomy", J CARDIOTHO, 14(2), 2000, pp. 166-170

Abstract

Objective: To assess whether subtle brain damage after carotid endarterectomy could he detected using serum levels of neuron-specific enolase (NSE) or S-100 beta protein. Design: Prospective noninterventional study. Setting: University hospital. Participants: Twenty-two patients undergoing carotid endarterectomy and 16patients undergoing repair of abdominal aortic aneurysm. Interventions: Serum levels of NSE and S-100 beta protein were measured inall patients before surgery and postoperatively at 12, 24, 36, and 48 hours. In patients undergoing carotid endarterectomy, neuropsychologic testing was performed before surgery and postoperatively at discharge from the hospital and after 3 months using a neuropsychologic test battery. Measurements and Main Results: Compared with abdominal aortic surgery patients, the preoperative serum concentration of NSE was significantly higher in carotid artery surgery patients. Postoperatively, the NSE serum level decreased significantly after uncomplicated carotid artery surgery, and the level was then similar to that in the aortic surgery patients. Before operation, the S-100 beta protein levels were similar in the two groups, but a significant increase was seen in aortic surgery patients postoperatively. Neuropsychologic testing after uncomplicated carotid artery surgery revealed cognitive dysfunction in 2 of 20 (10%) of the patients after 5 days and 3 of16 (19%) of the patients after 3 months. There was no correlation between the change in cognitive function and the changes in blood levels of either NSE or S-100 beta protein. Conclusions:Subtle brain damage after carotid artery surgery could not he detected by measuring blood levels of NSE and S-100 beta protein. The NSE level was significantly higher before carotid artery surgery and decreased postoperatively to the level observed in aortic surgery. Copyright (C) 2000 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:53:15