Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Prevalence and clinical significance of anti-phospholipid antibodies in multiple sclerosis: a study of 89 patients
Autore:
Roussel, V; Yi, F; Jauberteau, MO; Couderq, C; Lacombe, C; Michelet, V; Gil, R; Couratier, P; Vallat, JM; Preudhomme, JL;
Indirizzi:
Immunol Lab, CNRS, ESA 6031, Poitiers, France Immunol Lab Poitiers France munol Lab, CNRS, ESA 6031, Poitiers, France Immunol Lab, CNRS, ESA 6031, Limoges, France Immunol Lab Limoges FranceImmunol Lab, CNRS, ESA 6031, Limoges, France Dept Neurol, Poitiers, France Dept Neurol Poitiers FranceDept Neurol, Poitiers, France Limoges Univ Hosp, Dept Neurol, Limoges, France Limoges Univ Hosp Limoges France niv Hosp, Dept Neurol, Limoges, France
Titolo Testata:
JOURNAL OF AUTOIMMUNITY
fascicolo: 3, volume: 14, anno: 2000,
pagine: 259 - 265
SICI:
0896-8411(200005)14:3<259:PACSOA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; CENTRAL-NERVOUS-SYSTEM; ANTIPHOSPHOLIPID ANTIBODIES; ANTINUCLEAR ANTIBODIES; ANTICARDIOLIPIN ANTIBODIES; ENDOTHELIAL-CELLS; CARDIOLIPIN ANTIBODIES; NEUROLOGICAL DISORDERS; LUPOID SCLEROSIS; OPTIC NEURITIS;
Keywords:
anti-beta(2) glycoprotein I antibodies; anti-cardiolipin antibodies; anti-myelin antibodies; multiple sclerosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Preud'homme, JL Univ Hosp, Lab Immunol & Immunopathol, CNRS, ESA 6031, BP 577, F-86021 Poitiers, France Univ Hosp BP 577 Poitiers France F-86021 Poitiers, France
Citazione:
V. Roussel et al., "Prevalence and clinical significance of anti-phospholipid antibodies in multiple sclerosis: a study of 89 patients", J AUTOIMMUN, 14(3), 2000, pp. 259-265

Abstract

The prevalence of serum anti-phospholipid antibodies (aPL) was evaluated in multiple sclerosis (MS) patients to search for a possible association with a distinct form of the disease. Anti-cardiolipin antibodies (Ab) (aCL) and anti-beta 2 glycoprotein I Ab (a beta 2GPI) were measured together with antinuclear Ab (ANA), anti-double-stranded DNA Ab (anti-ds DNA) and antimyelin Ab in 89 patients. Twenty-nine (32.6%) patients had serum aPL, 19 x aCL (15 of the IgG and four of the IgM isotype), 14 a beta 2GPI (two IgG and 12IgM) (four of these patients had both Ab). Prevalence of aCL correlated with that of ANA, which were positive in 52 patients (P=0.005) and with antimyelin Ab detected in two patients (P = 0.046) but not with that of anti-ds DNA (mostly of the IgM class) detected in 28% of case by ELISA. No correlation could be found between aPL and age, sex, duration of the disease from diagnosis, category of MS, clinical course, clinical symptoms, serum IgM levels nor atypical lesions by magnetic resonance imaging. Hence, aCL and a beta 2GPI are neither rare in MS nor associated with a specific clinical formof the disease and they cannot be a diagnosis exclusion criteria. (C) 2000Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:25:20