Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Sex chromosomal analysis of spermatozoa from infertile men using fluorescence in situ hybridization
Autore:
Nishikawa, N; Murakami, I; Ikuta, K; Suzumori, K;
Indirizzi:
Nagoya City Univ, Sch Med, Dept Obstet & Gynecol, Mizuho Ku, Nagoya, Aichi4678602, Japan Nagoya City Univ Nagoya Aichi Japan 4678602 , Nagoya, Aichi4678602, Japan
Titolo Testata:
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
fascicolo: 2, volume: 17, anno: 2000,
pagine: 97 - 102
SICI:
1058-0468(200002)17:2<97:SCAOSF>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACYTOPLASMIC SPERM INJECTION; INSITU HYBRIDIZATION; Y-CHROMOSOME; NUCLEI; ABNORMALITIES; ANEUPLOIDY; DISOMY; FISH; SEGREGATION; MALES;
Keywords:
FISH; infertile men; sex chromosome aneuploidy; spermatozoa; XY disomy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Nishikawa, N Nagoya City Univ, Sch Med, Dept Obstet & Gynecol, Mizuho Ku, Mizuho Cho, Nagoya, Aichi 4678602, Japan Nagoya City Univ Mizuho Cho NagoyaAichi Japan 4678602 Japan
Citazione:
N. Nishikawa et al., "Sex chromosomal analysis of spermatozoa from infertile men using fluorescence in situ hybridization", J AS REPROD, 17(2), 2000, pp. 97-102

Abstract

Purpose: To confirm an association between male infertility and chromosomeaberrations of spermatozoa, we demonstrated the frequency of numerical abnormalities of spermatozoa from infertile men with abnormal semen parameterscompared with fertile controls. Method: Sperm cells from 10 infertile patients were investigated for disomy rates of sex chromosomes and chromosome 18 and diploidy by fluorescence in situ hybridization (FISH). All patients showed oligoasthenozoospermia with sperm counts 3-20 x 10(6)/ml and motile rates 0-40%. Results: Regarding XY disomy, a significantly higher frequency was found in 8 of 10 patients as compared to normal fertile men. The disomy rates of chromosome 18, XX, YY, and diploidy rate were not increased. Conclusions: There is an association between male infertility and embryo with aneuploidy of sex chromosomes. Counseling about possible genetic risks should be provided to the infertile couples planning assisted reproduction treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:01:36