Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Induction of apoptosis by hexamethylene bisacetamide is p53-dependent associated with telomerase activity but not with terminal differentiation
Autore:
Zhang, ZC; Liong, EC; Lau, TYH; Leung, KM; Fung, PCW; Tipoe, GL;
Indirizzi:
Univ Hong Kong, Dept Anat, Hong Kong, Hong Kong, Peoples R China Univ HongKong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Hong Kong Polytech Univ, Dept Opt & Radiog, Hong Kong, Hong Kong, Peoples R China Hong Kong Polytech Univ Hong Kong Hong Kong Peoples R China ples R China Univ Hong Kong, Dept Med, Div Med Phys, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 5, volume: 16, anno: 2000,
pagine: 887 - 892
SICI:
1019-6439(200005)16:5<887:IOABHB>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
P53-MEDIATED APOPTOSIS; MONOCLONAL-ANTIBODY; COLORECTAL-CANCER; P53; CELLS; INHIBITION; MUTATIONS;
Keywords:
apoptosis; differentiation; telomerase; p53; hexamethylene bisacetamide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Tipoe, GL Univ Hong Kong, Dept Anat, Li Shu Fan Bldg,Sassoon Rd, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Li Shu Fan Bldg,Sassoon Rd HongKong Hong Kong Peoples R China
Citazione:
Z.C. Zhang et al., "Induction of apoptosis by hexamethylene bisacetamide is p53-dependent associated with telomerase activity but not with terminal differentiation", INT J ONCOL, 16(5), 2000, pp. 887-892

Abstract

The present study investigated the relationships amongst apoptosis, terminal differentiation and telomerase activity in human colon carcinoma cells. We found that hexamethylene bisacetamide (HMBA) induced apoptosis in human colon carcinoma LoVo cells harbouring wild-type p53 but not in SW1116 cellsharbouring mutant p53. HMBA reduced telomerase activity in both colon carcinoma cells but it did not induce differentiation in the colon carcinoma cells. Taken together, our results suggest that HMBA can induce apoptosis viaa p53-dependent pathway, but apoptosis and terminal differentiation may beseparately regulated in LoVo cells. Inhibition of telomerase activity may activate apoptosis through a p53-dependent mechanism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 00:23:14