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Titolo:
Procalcitonin (PCT) in patients with abdominal sepsis
Autore:
Reith, HB; Mittelkotter, U; Wagner, R; Thiede, A;
Indirizzi:
Univ Wurzburg, Dept Surg, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 t Surg, D-97080 Wurzburg, Germany Ruhr Univ Bochum, Dept Surg, D-44892 Bochum, Germany Ruhr Univ Bochum Bochum Germany D-44892 pt Surg, D-44892 Bochum, Germany
Titolo Testata:
INTENSIVE CARE MEDICINE
, volume: 26, anno: 2000, supplemento:, 2
pagine: S165 - S169
SICI:
0342-4642(2000)26:<S165:P(IPWA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-REACTIVE PROTEIN; SEPTIC PATIENTS; SERUM PROCALCITONIN; CYTOKINE RELEASE; INTERLEUKIN-6; PLASMA;
Keywords:
peritonitis; sepsis; septic courses; diagnosis; cytokines; procalcitonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Reith, HB Univ Wurzburg, Dept Surg, Josef Schneider Str 2, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 2 Wurzburg Germany D-97080 ny
Citazione:
H.B. Reith et al., "Procalcitonin (PCT) in patients with abdominal sepsis", INTEN CAR M, 26, 2000, pp. S165-S169

Abstract

Background: To assess the accuracy of procalcitonin as a measure of severity in patients with septic abdominal illnesses and the sepsis syndrome, to compare measurements with those of other inflammatory mediators, and to predict outcome. Methods: We carried out a prospective clinical study from 246 patients with infective or septic episodes confirmed at laparotomy and 66 patients undergoing elective operations who acted as controls. Specimens of blood for measurement of cytokine concentrations determination were obtained daily fromseptic patients. In the control group specimens were obtained before operation, at the end of operation, and on each of the following days until normal recovery (day 10). Every two weeks up to 3 months for patients with metastases, who were being followed up. Results: Compared with other cytokines such as tumor necrosis factor aa and interleukin 6 procalcitonin was closely related to the development of infective and septic complications. 59 of 246 patients (24%) with sepsis died. Procalcitonin concentrations preoperatively [median 2.05 compared with 4.2ng/ml (p = 0.08)] (Mann-Whitney U-test) did not differ, but those on the days 1, 4 and at the end differed significantly [day 1: 4.9 compared with 13.8 ng/ml (p < 0.01); day 4: 4.8 compared with 13.0 ng/ml (p < 0.01) and 0.4compared with 13.25 ng/ml (p < 0.01) at the end of the study]. In the control group only 7 (1.6%) of all blood samples, were detected outside the normal range (up to 0.8 ng/ml). Conclusions: Procalcitonin is a new indicator of infection and sepsis. TNFand IL-6 concentrations always rise after major operations and fall in theabsence of infection, indicating operative trauma. Procalcitonin is sensitive in detecting infective complications. Under routine conditions the procalcitonin concentrations seems to be valid, reproducible and detectable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:44:47