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Titolo:
REDUCED BASAL GANGLIA VOLUMES IN TRICHOTILLOMANIA MEASURED VIA MORPHOMETRIC MAGNETIC-RESONANCE-IMAGING
Autore:
OSULLIVAN RL; RAUCH SL; BREITER HC; GRACHEV ID; BAER L; KENNEDY DN; KEUTHEN NJ; SAVAGE CR; MANZO PA; CAVINESS VS; JENIKE MA;
Indirizzi:
MASSACHUSETTS GEN HOSP E,DEPT PSYCHIAT,PSYCHIAT NEUROSCI PROGRAM CHARLESTOWN MA 02129 MASSACHUSETTS GEN HOSP E,DEPT RADIOL CHARLESTOWN MA 02129 MASSACHUSETTS GEN HOSP E,DEPT NEUROL CHARLESTOWN MA 02129 HARVARD UNIV,SCH MED CHARLESTOWN MA 00000
Titolo Testata:
Biological psychiatry
fascicolo: 1, volume: 42, anno: 1997,
pagine: 39 - 45
SICI:
0006-3223(1997)42:1<39:RBGVIT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; TOURETTES-SYNDROME; CAUDATE-NUCLEUS; THALAMOCORTICAL CIRCUITS; MRI; BRAIN; ABNORMALITIES; NEUROANATOMY;
Keywords:
MORPHOMETRIC MAGNETIC RESONANCE IMAGING; TRICHOTILLOMANIA; BASAL GANGLIA; PUTAMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
R.L. Osullivan et al., "REDUCED BASAL GANGLIA VOLUMES IN TRICHOTILLOMANIA MEASURED VIA MORPHOMETRIC MAGNETIC-RESONANCE-IMAGING", Biological psychiatry, 42(1), 1997, pp. 39-45

Abstract

A morphometric magnetic resonance imaging (MRI) study compared volumes of brain structures in 10 female subjects with trichotillomania (repetitive hair-pulling) versus 10 normal controls matched for sex, age, handedness, and education. Three-dimensional MRI scans were blindly normalized and segmented using well-characterized semiautomated intensity and differential contour algorithms by signal intensity-frequency histograms. Consistent with one a priori hypothesis, left putamen volumewas found to be significantly smaller in trichotillomania subjects ascompared with normal matched controls. This is the first report of a structural brain abnormality in trichotillomania. Results are discussed in terms of putative relationships between trichotillomania, Tourette's syndrome, and obsessive-compulsive disorder. (C) 1997 Society of Biological Psychiatry.

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Documento generato il 04/04/20 alle ore 01:51:08