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Titolo:
The liver as a site of T-cell apoptosis: graveyard, or krilling field?
Autore:
Crispe, IN; Dao, T; Klugewitz, K; Mehal, WZ; Metz, DP;
Indirizzi:
Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 Immunobiol Sect, New Haven, CT 06520 USA
Titolo Testata:
IMMUNOLOGICAL REVIEWS
, volume: 174, anno: 2000,
pagine: 47 - 62
SICI:
0105-2896(200004)174:<47:TLAASO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATITIS-C VIRUS; ISCHEMIA-REPERFUSION INJURY; SMALL-BOWEL TRANSPLANTATION; PORTAL VENOUS IMMUNIZATION; CULTURED MOUSE HEPATOCYTES; FAS-MEDIATED APOPTOSIS; DONOR SPLEEN-CELLS; IN-VIVO; TOLERANCE INDUCTION; TRANSGENIC MICE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
130
Recensione:
Indirizzi per estratti:
Indirizzo: Crispe, IN Yale Univ, Sch Med, Immunobiol Sect, 310 Cedar St, New Haven, CT 06520 USA Yale Univ 310 Cedar St New Haven CT USA 06520 ven, CT 06520 USA
Citazione:
I.N. Crispe et al., "The liver as a site of T-cell apoptosis: graveyard, or krilling field?", IMMUNOL REV, 174, 2000, pp. 47-62

Abstract

The liver is a site at which apoptotic CD8(+) cells accumulate during the clearance phase of peripheral immune responses. Normal mouse liver containsan unusual mixture of lymphocytes in which natural killer (NK) and NK-T cells are abundant and apoptotic T cells are present, and we interpret these cell populations as, respectively, agents and targets of an intrahepatic T-cell trapping and killing mechanism. In support of this idea, direct perfusion of activated lymphocyte populations through the normal liver results inthe selective retention of activated CD8(+) T cells. T cells trapped in this manner undergo apoptosis in the liver. This mechanism could explain the importance of the liver in oral tolerance, the phenomenon of tolerance induced by portal vein infusion of antigenic cells, the tolerance to allogeneicliver allografts, and the persistence of some liver pathogens including hepatitis C.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:03:27