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Titolo:
Can initial serum Cyfra 21-1, SCC antigen, and TPA levels in squamous cellcervical cancer predict lymph node metastases or prognosis?
Autore:
Gaarenstroom, KN; Kenter, GG; Bonfrer, JMG; Korse, CM; Van de Vijver, MJ; Fleuren, GJ; Trimbos, JB;
Indirizzi:
Leiden Univ, Dept Gynecol, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands Leiden Univ, Dept Pathol, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands Netherlands Canc Inst, Dept Clin Chem, Amsterdam, Netherlands Netherlands Canc Inst Amsterdam Netherlands hem, Amsterdam, Netherlands
Titolo Testata:
GYNECOLOGIC ONCOLOGY
fascicolo: 1, volume: 77, anno: 2000,
pagine: 164 - 170
SICI:
0090-8258(200004)77:1<164:CISC2S>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE POLYPEPTIDE ANTIGEN; CARCINOMA ANTIGEN; UTERINE CERVIX; MULTIVARIATE-ANALYSIS; RADICAL HYSTERECTOMY; CLINICAL-VALUE; TUMOR-MARKER; STAGE-IB; PRETREATMENT; RISK;
Keywords:
cervical cancer; Cyfra 21-1; TPA; SCC-Ag; serum markers; lymph node metastases; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Gaarenstroom, KN Leiden Univ, Dept Gynecol, NL-2300 RC Leiden, NetherlandsLeiden Univ Leiden Netherlands NL-2300 RC , Netherlands
Citazione:
K.N. Gaarenstroom et al., "Can initial serum Cyfra 21-1, SCC antigen, and TPA levels in squamous cellcervical cancer predict lymph node metastases or prognosis?", GYNECOL ONC, 77(1), 2000, pp. 164-170

Abstract

Objective. The aim of this study was to determine whether lymph node metastases or prognosis can be predicted by initial serum Cyfra 21-1, tissue polypeptide antigen (TPA), and squamous cell carcinoma antigen (SCC-Ag) levelsin squamous cell cervical cancer. Methods. Pretreatment serum levels of 92 patients were correlated with clinicopathologic parameters and prognostic data. The clinical performance of the tests was evaluated by their receiver operating characteristic curves. The prognostic power of the variables was assessed using Cox regression analysis. Results. Serum levels of each marker were significantly related to tumor stage, size, and depth of infiltration. The clinical performance of each marker in predicting lymph node metastases or parametrial involvement was poor. In the stepwise Cox regression analysis, regarding patients with early stage cervical cancer (stage Ib/IIa, n = 63), tumor size (P = 0.0005) was theonly independent prognostic factor for disease-free interval, Lymph node status (P = 0.0014), tumor size (P = 0.004), and parametrial involvement (P = 0.025) were independent risk factors for survival. Considering all patients with stages la through IVb disease, tumor size (P = 0.0001) and TPA level (P = 0.026) were independent risk factors for disease-free interval, whereas tumor size (P = 0.0001) and parametrial involvement (P = 0.0002) were risk factors for survival. Conclusions. Pretreatment Cyfra 21-1, TPA, and SCC-Ag levels were stronglyrelated to tumor burden, but insufficiently reliable for identifying patients at risk of the presence of lymph node metastases or parametrial involvement. Serum levels of each marker showed no independent prognostic value inearly stage cervical cancer. (C) 2000 Academic Press.

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Documento generato il 05/04/20 alle ore 22:53:55