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Titolo:
The possible role of p53 and bcl-2 expression in cervical carcinomas and their premalignant lesions
Autore:
Dimitrakakis, C; Kymionis, G; Diakomanolis, E; Papaspyrou, I; Rodolakis, A; Arzimanoglou, I; Leandros, E; Michalas, S;
Indirizzi:
Alexandra Hosp, Sch Med, Dept Gynecol & Obstet 1, Athens, Greece AlexandraHosp Athens Greece d, Dept Gynecol & Obstet 1, Athens, Greece Cornell Univ, Weill Med Coll, Dept Obstet & Gynecol, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 t Obstet & Gynecol, Ithaca, NY 14853 USA
Titolo Testata:
GYNECOLOGIC ONCOLOGY
fascicolo: 1, volume: 77, anno: 2000,
pagine: 129 - 136
SICI:
0090-8258(200004)77:1<129:TPROPA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGNOSTIC-SIGNIFICANCE; DOWN-REGULATION; UTERINE CERVIX; BREAST-CANCER; APOPTOSIS; PROTEIN; OVEREXPRESSION; ONCOPROTEIN; THERAPY; TUMORS;
Keywords:
p53; bcl-2; cervix; carcinogenesis; immunohistochemistry; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Dimitrakakis, C 8 Niriidon Str, Athens 16673, Greece 8 Niriidon Str Athens Greece 16673 Athens 16673, Greece
Citazione:
C. Dimitrakakis et al., "The possible role of p53 and bcl-2 expression in cervical carcinomas and their premalignant lesions", GYNECOL ONC, 77(1), 2000, pp. 129-136

Abstract

Objective. The purpose of this study was to assess the expression and clinical significance of bcl-2 and p53 in the progression of cervical neoplasias. Methods. One hundred seventy-one cervical specimens, consisting of normal cervical epithelium (n = 13), lesions with histological features of HPV infection (n = 14), CIN (cervical intraepithelial neoplasia) lesions (n = 63),and cervical carcinomas (n 81) were examined immunohistochemically in paraffin sections. Results. Twenty-three specimens showed p53 expression [3/20 (15%) CIN III,18/63 (29%) ISCC (invasive squamous cervical carcinoma), and 2/18 (11%) adenocarcinomas] while 63 cases expressed the bcl-2 gene [10/13 (77%) normal,0/14(0%) condylomas, 6/23 (26%) CIN I, 9/20 (45%) CIN II, 15/20 (75%) CIN III, 18/63 (29%) ISCC, and 5/18 (28%) adenocarcinomas]. The expression of bcl-2 was found to increase in direct relation to the grade of CIN (P = 0.02) whereas such a trend was not observed for p53. p53 was not detected in normal or premalignant lesions (except 3 out of 20 cases of CIN III). There was no significant correlation between the expression of p53 and the histological type of cervical carcinoma, even though expression of p53 was higher in ISCC than in adenocarcinomas (29% vs 11%, respectively). In cervical cancer patients, expression of bcl-2 was correlated to a greater than 5-year survival (P < 0.01) while no prognostic significance of p53 expression was found. Conclusion. Evaluation of bcl-2 expression may provide additional and independent prognostic information for the clinical course of the disease and therefore to be developed as a prognostic indicator for cervical cancer. (C)2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:05:58