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Titolo:
Parasympathetic non-adrenergic, mon-cholinergic-induced protein synthesis and mitogenic activity in rat parotid glands
Autore:
Ekstrom, J; Havel, GE; Reinhold, AC;
Indirizzi:
Univ Gothenburg, Dept Pharmacol, Inst Physiol & Pharmacol, S-40530 Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden S-40530 ol, S-40530 Gothenburg, Sweden
Titolo Testata:
EXPERIMENTAL PHYSIOLOGY
fascicolo: 2, volume: 85, anno: 2000,
pagine: 171 - 176
SICI:
0958-0670(200003)85:2<171:PNMPSA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE-INTESTINAL-PEPTIDE; SALIVARY-GLANDS; ELECTRICAL-STIMULATION; NERVE-STIMULATION; REFLEX SECRETION; EVOKED SECRETION; ACINAR GRANULES; SUBSTANCE-P; ATROPINE; INNERVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Ekstrom, J Univ Gothenburg, Dept Pharmacol, Inst Physiol & Pharmacol, Box 431, S-40530 Gothenburg, Sweden Univ Gothenburg Box 431 Gothenburg Sweden S-40530 burg, Sweden
Citazione:
J. Ekstrom et al., "Parasympathetic non-adrenergic, mon-cholinergic-induced protein synthesis and mitogenic activity in rat parotid glands", EXP PHYSIOL, 85(2), 2000, pp. 171-176

Abstract

Electrical stimulation of the parasympathetic auriculo-temporal nerve (40 Hz, 30 min), in the anaesthetized rat under alpha- and beta-adrenoceptor blockade, increased [H-3]thymidine and [H-3]leucine uptake into the parotid glands by 80 and 263%, respectively. The increase in response to parasympathetic stimulation was almost the same ([H-3]thymidine 82% and [H-3]leucine 283%) when atropine (2 mg kg(-1) I.P. or I.V.) was included in the pretreatment. Neither intravenous infusion of vasoactive intestinal peptide (0.5-20 mu g kg(-1) min(-1), 30 min) nor of bethanechol (10 mu g kg(-1) min(-1), 30min), under adrenoceptor blockade, increased the uptake of [H-3]thymidine into the glands. However, these drugs increased [H-3]leucine uptake, and incombination they interacted positively. Whereas vasoactive intestinal peptide is likely to be involved in the parasympathetic nerve-evoked protein synthesis, the nature of the non-adrenergic, non-cholinergic component(s) involved in the mitogenic response is presently unknown.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 02:31:31