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Titolo:
Neuronal nicotinic receptors in non-neuronal cells: new mediators of tobacco toxicity?
Autore:
Conti-Fine, BM; Navaneetham, D; Lei, S; Maus, ADJ;
Indirizzi:
Univ Minnesota, Dept Biochem Mol Biol & Biophys, St Paul, MN 55108 USA Univ Minnesota St Paul MN USA 55108 Biol & Biophys, St Paul, MN 55108 USA Univ Minnesota, Dept Pharmacol, St Paul, MN 55108 USA Univ Minnesota St Paul MN USA 55108 Dept Pharmacol, St Paul, MN 55108 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-3, volume: 393, anno: 2000,
pagine: 279 - 294
SICI:
0014-2999(20000330)393:1-3<279:NNRINC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCARINIC ACETYLCHOLINE-RECEPTORS; VERTEBRATE SKELETAL-MUSCLE; BUNGAROTOXIN BINDING-SITES; VASCULAR ENDOTHELIAL-CELLS; CHOLINE-ACETYLTRANSFERASE; CALCIUM PERMEABILITY; MYASTHENIA-GRAVIS; MATERNAL SMOKING; ULTRASTRUCTURAL-LOCALIZATION; HUMAN KERATINOCYTES;
Keywords:
nicotine; nicotinic receptor; non-neuronal; lung; blood vessel; skin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
101
Recensione:
Indirizzi per estratti:
Indirizzo: Conti-Fine, BM Univ Minnesota, Dept Biochem Mol Biol & Biophys, 1479 Gortner Ave, St Paul, MN 55108 USA Univ Minnesota 1479 Gortner Ave St Paul MN USA 55108 08 USA
Citazione:
B.M. Conti-Fine et al., "Neuronal nicotinic receptors in non-neuronal cells: new mediators of tobacco toxicity?", EUR J PHARM, 393(1-3), 2000, pp. 279-294

Abstract

The nicotinic acetylcholine receptors are prototypic ionotropic receptors that mediate fast synaptic transmission. However, also non-excitable cells,and particularly the tegumental cells that line external and internal bodysurfaces, express acetylcholine receptors of neuronal type sensitive to nicotine. Bronchial epithelial cells, endothelial cells of blood vessels and skin keratinocytes express neuronal nicotinic receptors composed of alpha(3), alpha(5), beta(2) and beta(4) subunits, similar to those expressed in sympathetic ganglia, and neuronal nicotinic receptors composed of alpha(7) subunits. Neuronal nicotinic receptors in tegumental cells are involved in modulating cell shape and motility, and therefore in maintaining the integrity of the surfaces lined by those cells. Neuronal nicotinic receptors in non-neuronal tissues may modulate other functions, including cell proliferation and differentiation. Acetylcholine is synthesized, secreted and degraded by a variety of cells, including the tegumental cells that express neuronalnicotinic receptors. Thus, acetylcholine may function as a local "hormone"that is able to modulate cell functions that require fast adaptation to new conditions. The presence of neuronal nicotinic receptors sensitive to nicotine in tissues known to be involved in tobacco toxicity, like bronchi andblood vessels, raises the possibility that they mediate some of the toxic effects of smoking. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:05:42