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Titolo:
Effect of AMPA receptor modulators on hippocampal and cortical function
Autore:
Black, MD; Wotanis, J; Schilp, DE; Hanak, SE; Sorensen, SM; Wettstein, JG;
Indirizzi:
CNS Res, Aventis Pharmaceut, Bridgewater, NJ 08807 USA CNS Res Bridgewater NJ USA 08807 is Pharmaceut, Bridgewater, NJ 08807 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 394, anno: 2000,
pagine: 85 - 90
SICI:
0014-2999(20000407)394:1<85:EOARMO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMATE-OPERATED CHANNELS; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONATE; KAINATE RECEPTORS; RECOMBINANT AMPA; CYCLOTHIAZIDE; PERMEABILITY; EXPRESSION; ANIRACETAM; SUBUNIT; CALCIUM;
Keywords:
AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid); AMPA receptor modulator; cortex; hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Black, MD CNS Res, Aventis Pharmaceut, Bridgewater, NJ 08807 USA CNS Res Bridgewater NJ USA 08807 eut, Bridgewater, NJ 08807 USA
Citazione:
M.D. Black et al., "Effect of AMPA receptor modulators on hippocampal and cortical function", EUR J PHARM, 394(1), 2000, pp. 85-90

Abstract

Attention has focused on drugs that modulate AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid) receptors because of their potential for enhancing memory and treating certain pathologies that involve glutamatergic neurotransmission. The aim of this study was to compare and contrast the functionality of positive allosteric modulators of AMPA receptors in thehippocampus and medial prefrontal cortex. Electrically stimulated EPSPs (excitatory postsynaptic potential) in the hippocampus were augmented by CX516 [(1-quinoxaline-6-ylcarbonyl)piperidine], aniracetam and 1-BCP [(1-(1,3-benzodioxol-5-ylcarbonyl)piperidine] and not by cyclothiazide. Using grease gap electrophysiology, it was found that the mode of application dramatically altered the effect of the modulators of AMPA-induced depolarization. When added simultaneously with AMPA, aniracetam, 1-BCP and CX516 augmented theresponse in the frontal cortex. However, in the hippocampus, only aniracetam and cyclothiazide augmented the response when simultaneously added to AMPA. Therefore, in addition to regional variations, there appears to be differences in modulator response dependent upon whether a response is generated endogenously or exogenously by AMPA. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:19:52