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Titolo:
Role of Qa-1(b)-binding receptors in the specificity of developing NK cells
Autore:
Salcedo, M; Colucci, F; Dyson, PJ; Cotterill, LA; Lemonnier, FA; Kourilsky, P; Di Santo, JP; Ljunggren, HG; Abastado, JP;
Indirizzi:
Inst Pasteur, INSERM, U277, Unite Biol Mol Gene, F-75724 Paris, France Inst Pasteur Paris France F-75724 e Biol Mol Gene, F-75724 Paris, France Hop Necker Enfants Malad, INSERM, U429, Paris, France Hop Necker Enfants Malad Paris France alad, INSERM, U429, Paris, France Hammersmith Hosp, Royal Postgrad Med Sch, MRC, Ctr Clin Sci, London W12 0HS, England Hammersmith Hosp London England W12 0HS lin Sci, London W12 0HS, England Inst Pasteur, Dept SIDA Retrovirus, Unite Immun Cellulaire Antivirale, Paris, France Inst Pasteur Paris France te Immun Cellulaire Antivirale, Paris, France Karolinska Inst, Ctr Microbiol & Tumor Biol, Stockholm, Sweden Karolinska Inst Stockholm Sweden robiol & Tumor Biol, Stockholm, Sweden
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 4, volume: 30, anno: 2000,
pagine: 1094 - 1101
SICI:
0014-2980(200004)30:4<1094:ROQRIT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; TARGET-CELLS; T-CELLS; HLA-E; COMPLEX; MHC; RECOGNITION; EXPRESSION; QA-1(B); MICE;
Keywords:
NK cell; ontogeny; MHC class I; Qa-1-binding receptor; tetramer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Salcedo, M Ctr Rech Biomed Cordeliers, LUTI, IDM Res Lab, 15 Rue Ecole Med, F-75006 Paris, France Ctr Rech Biomed Cordeliers 15 Rue Ecole Med Paris France F-75006
Citazione:
M. Salcedo et al., "Role of Qa-1(b)-binding receptors in the specificity of developing NK cells", EUR J IMMUN, 30(4), 2000, pp. 1094-1101

Abstract

NK cells acquire the ability to recognize MHC class I molecules during development. Studies with Qa-1(b) tetramers (Qa-1 tetramers) showed that nearly all NK1.1(+) cells from newborn C57BL/6 mice express Qa-1 binding receptors. Cytotoxic activity of these cells is fully inhibited by Qa-1 ligands ontarget cells. In contrast, neither receptors for H-2K(b) nor H-2D(b) were observed on NK1.1(+) cells from newborn mice. After birth, frequencies of Qa-1 tetramer(+)/ NK1.1(+)cells gradually decrease as the number of Ly49(+)/NK1.1(+)cells increases. Cell transfer studies showed that Qa-1 tetramer(+)cells from newborn mice do not lose expression of Qa-1 receptors, but thatthey further acquire expression of Ly49 molecules. Acquisition of Qa-1-binding receptors appears largely independent of host MHC class I molecules, as observed in studies using beta 2-microglobulin-deficient (beta 2m(-/-)) mice as well as K-b/Db-/- and K-b/D-b/beta 2m(-/-) mice. The present resultssuggest that Qa-l-binding receptors play an important role in the specificity of developing NK cells, and suggest that these cells rely mainly on inhibitory receptors specific for non-classical MHC class I molecules to maintain self tolerance during the first weeks of life.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 22:23:54