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Titolo:
The insulin-like growth factor-I receptor is regulated by CD28 and protects activated T cells from apoptosis
Autore:
Walsh, PT; OConnor, R;
Indirizzi:
Natl Univ Ireland Univ Coll Cork, Dept Biochem, Cell Biol Lab, Cork, Ireland Natl Univ Ireland Univ Coll Cork Cork Ireland l Biol Lab, Cork, Ireland
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 4, volume: 30, anno: 2000,
pagine: 1010 - 1018
SICI:
0014-2980(200004)30:4<1010:TIGFRI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYC-INDUCED APOPTOSIS; HEMATOPOIETIC-CELLS; SURVIVAL; EXPRESSION; LIGAND; ANTIGEN; BCL-2; DEATH; REQUIREMENT; CYTOKINES;
Keywords:
insulin-like growth factor-I receptor; apoptosis; GD28; Fas; Bcl-xl;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: O'Connor, R Natl Univ Ireland Univ Coll Cork, Dept Biochem, Cell Biol Lab,Lee Maltings, Cork, Ireland Natl Univ Ireland Univ Coll Cork Lee Maltings Cork Ireland d
Citazione:
P.T. Walsh e R. O'Connor, "The insulin-like growth factor-I receptor is regulated by CD28 and protects activated T cells from apoptosis", EUR J IMMUN, 30(4), 2000, pp. 1010-1018

Abstract

Go-stimulatory signals through the CD28 receptor enhance the survival of Tcells that have their antigen receptor (TCR) engaged. Here we show that stimulation through the CD28 receptor in the absence of TCR engagement with either an anti-CD28 cross-linking antibody or the CD80 ligand transiently increases expression of the insulin-like growth factor-1 receptor (IGF-IR) onT cells. Antibodies that block signaling through the IGF-IR decrease the survival of T cells activated through the TCR and CD28 in the presence of IL-2 by more than 50%, and also enhance susceptibility to Fas-induced apoptosis. CD28 stimulation increases IGF-IR expression on Jurkat cells, and exogenously added IGF-I can protect these cells from Fas-induced apoptosis. We conclude that CD28-mediated enhancement of IGF-IR expression provides activated T cells with essential survival signals that are independent of survival mediated by IL-2 and Bcl-xl.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 22:49:06