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Titolo:
Uncovering molecular mechanisms involved in activation of G protein-coupled receptors
Autore:
Gether, U;
Indirizzi:
Univ Copenhagen, Panum Inst, Dept Med Physiol, Div Mol & Cellular Physiol,DK-2200 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-2200 l,DK-2200 Copenhagen, Denmark
Titolo Testata:
ENDOCRINE REVIEWS
fascicolo: 1, volume: 21, anno: 2000,
pagine: 90 - 113
SICI:
0163-769X(200002)21:1<90:UMMIIA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELTA-OPIOID RECEPTOR; TERMINAL EXTRACELLULAR DOMAIN; THYROTROPIN-RELEASING-HORMONE; DOPAMINE D2 RECEPTOR; LIGAND-BINDING SITE; MEMBRANE-SPANNING SEGMENT; BETA-ADRENERGIC-RECEPTOR; ANGIOTENSIN-II RECEPTOR; MUSCARINIC ACETYLCHOLINE-RECEPTORS; TACHYKININ NONPEPTIDE ANTAGONISTS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
290
Recensione:
Indirizzi per estratti:
Indirizzo: Gether, U Univ Copenhagen, Panum Inst, Dept Med Physiol, Div Mol & Cellular Physiol,12-5-22, DK-2200 Copenhagen, Denmark Univ Copenhagen 12-5-22 Copenhagen Denmark DK-2200 gen, Denmark
Citazione:
U. Gether, "Uncovering molecular mechanisms involved in activation of G protein-coupled receptors", ENDOCR REV, 21(1), 2000, pp. 90-113

Abstract

G protein-coupled, seven-transmembrane segment receptors (GPCRs or 7TM receptors), with more than 1000 different members, comprise the largest superfamily of proteins in the body. Since the cloning of the first receptors more than a decade ago, extensive experimental work has uncovered multiple aspects of their function and challenged many traditional paradigms. However, it is only recently that we are beginning to gain insight into some of the most fundamental questions in the molecular function of this class of receptors. How can, for example, so many chemically diverse hormones, neurotransmitters, and other signaling molecules activate receptors believed to sharea similar overall tertiary structure? What is the nature of the physical changes linking agonist binding to receptor activation and subsequent transduction of the signal to the associated G protein on the cytoplasmic side ofthe membrane and to other putative signaling pathways? The goal of the present review is to specifically address these questions as well as to depictthe current awareness about GPCR structure-function relationships in general.

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Documento generato il 22/01/20 alle ore 12:36:49