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Titolo:
Natural patterns of activity and long-term synaptic plasticity
Autore:
Paulsen, O; Sejnowski, TJ;
Indirizzi:
Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England Univ Oxford Oxford England OX1 3QT pt Pharmacol, Oxford OX1 3QT, England Univ Calif San Diego, Howard Hughes Med Inst, Salk Inst, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 k Inst, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 t Biol, La Jolla, CA 92093 USA
Titolo Testata:
CURRENT OPINION IN NEUROBIOLOGY
fascicolo: 2, volume: 10, anno: 2000,
pagine: 172 - 179
SICI:
0959-4388(200004)10:2<172:NPOAAL>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEOCORTICAL PYRAMIDAL NEURONS; PROPAGATING ACTION-POTENTIALS; TEMPORAL-ORDER; CELL DENDRITES; THETA-RHYTHM; IN-VIVO; HIPPOCAMPUS; MEMORY; RAT; MODEL;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Paulsen, O Univ Oxford, Dept Pharmacol, Mansfield Rd, Oxford OX1 3QT, England Univ Oxford Mansfield Rd Oxford England OX1 3QT 1 3QT, England
Citazione:
O. Paulsen e T.J. Sejnowski, "Natural patterns of activity and long-term synaptic plasticity", CUR OP NEUR, 10(2), 2000, pp. 172-179

Abstract

Long-term potentiation (LSP) of synaptic transmission is traditionally elicited by massively synchronous, high-frequency inputs, which rarely occur naturally. Recent in vitro experiments have revealed that both LTP and long-term depression (LTD) can arise by appropriately pairing weak synaptic inputs with action potentials in the postsynaptic cell. This discovery has generated new insights into the conditions under which synaptic modification may occur in pyramidal neurons in vivo. First, it has been shown that the temporal order of the synaptic input and the postsynaptic spike within a narrow temporal window determines whether LTP or LTD is elicited, according to atemporally asymmetric Hebbian learning rule. Second, backpropagating action potentials are able to serve as a global signal for synaptic plasticity in a neuron compared with local associative interactions between synaptic inputs on dendrites. Third, a specific temporal pattern of activity - postsynaptic bursting - accompanies synaptic potentiation in adults.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:57:53